Evidence map›Paper›PMID 29074589›Full record

ArticleArteriosclerosis, thrombosis, and vascular biology2017

ABCA1-Derived Nascent High-Density Lipoprotein-Apolipoprotein AI and Lipids Metabolically Segregate.

Bingqing Xu, Baiba K Gillard, Antonio M Gotto, Corina Rosales, Henry J Pownall

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Arteriosclerosis, thrombosis, and vascular biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
5.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 42 citations in OpenAlex.

  1. Review
  2. Article
  3. Interaction betweenNutrients · 2023
    Article
  4. Different Pathways of Cellular Cholesterol Efflux.Cell biochemistry and biophysics · 2022
    Review
  5. HDL and Lipid Metabolism.Advances in experimental medicine and biology · 2022
    Article
  6. High Free Cholesterol Bioavailability Drives the Tissue Pathologies in Scarb1Arteriosclerosis, thrombosis, and vascular biology · 2021
    Article
  7. Review
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Reporting Sex and Sex Differences in Preclinical Studies.Arteriosclerosis, thrombosis, and vascular biology · 2018
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 2 countries.

Bingqing XuFrom the Center for Bioenergetics and Department of Medicine, Houston Methodist Research Institute, TX (B.X., B.K.G., A.M.G., C.R., H.J.P.); and Department of Cardiovascular Medicine, Xiangya Hospital, Central South University, Changsha, China (B.X.).
Baiba K GillardFrom the Center for Bioenergetics and Department of Medicine, Houston Methodist Research Institute, TX (B.X., B.K.G., A.M.G., C.R., H.J.P.); and Department of Cardiovascular Medicine, Xiangya Hospital, Central South University, Changsha, China (B.X.).
Antonio M GottoFrom the Center for Bioenergetics and Department of Medicine, Houston Methodist Research Institute, TX (B.X., B.K.G., A.M.G., C.R., H.J.P.); and Department of Cardiovascular Medicine, Xiangya Hospital, Central South University, Changsha, China (B.X.).
Corina RosalesFrom the Center for Bioenergetics and Department of Medicine, Houston Methodist Research Institute, TX (B.X., B.K.G., A.M.G., C.R., H.J.P.); and Department of Cardiovascular Medicine, Xiangya Hospital, Central South University, Changsha, China (B.X.).
Henry J PownallFrom the Center for Bioenergetics and Department of Medicine, Houston Methodist Research Institute, TX (B.X., B.K.G., A.M.G., C.R., H.J.P.); and Department of Cardiovascular Medicine, Xiangya Hospital, Central South University, Changsha, China (B.X.). hjpownall@HoustonMethodist.org.
Central South University · CN

Funding

Therapeutic Approaches to Dysregulated HDL MetabolismR01HL056865 · NHLBI · METHODIST HOSPITAL RESEARCH INSTITUTE · PI POWNALL, HENRY J. · 1997 to 2015
$5.2M
High Density Lipoprotein Biogenesis and SpeciationR01HL129767 · NHLBI · METHODIST HOSPITAL RESEARCH INSTITUTE · PI POWNALL, HENRY J., ROSALES, CORINA · 2016 to 2019
$2.3M
NHLBI NIH HHS R01 HL056865NHLBI NIH HHS R01 HL129767
6 · The paper itself

Abstract

objectiveReverse cholesterol transport comprises cholesterol efflux from ABCA1-expressing macrophages to apolipoprotein (apo) AI, giving nascent high-density lipoprotein (nHDL), esterification of nHDL-free cholesterol (FC), selective hepatic extraction of HDL lipids, and hepatic conversion of HDL cholesterol to bile salts, which are excreted. We tested this model by identifying the fates of nHDL-[ APPROACH AND

resultsDuring in vitro incubation of human serum, nHDL-[

conclusionsnHDL-FC, PL, and apo AI enter different pathways in vivo. Most nHDL-[

Indexed as

AnimalsApolipoprotein A-IATP Binding Cassette Transporter 1BiomarkersCell LineCholesterol EstersCholesterol, HDLChromatography, GelHalf-LifeHepatocytesHigh-Density Lipoproteins, Pre-betaHumansKineticsLiverMacrophagesMice, Inbred C57BLABCA1 protein, humanAbca1 protein, mouseAPOA1 protein, humanApolipoprotein A-IATP Binding Cassette Transporter 1BiomarkersCholesterol EstersCholesterol, HDLHigh-Density Lipoproteins, Pre-betaPhosphatidylcholine-Sterol O-AcyltransferasePhospholipidsapolipoprotein AIatherogenesischolesterollipidslipoprotein

Identifiers

PMID29074589
PMCPMC5831354
OpenAlexW2765761643

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.