CANTOS Trial Validates the Inflammatory Pathogenesis of Atherosclerosis: Setting the Stage for a New Chapter in Therapeutic Targeting.

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

35 citing papers in PubMed, 1 synthesis or guideline pooled it.

1. Interleukin-8 Gene -251 A/T (rs4073) Polymorphism and Coronary Artery Disease Risk: A Meta-Analysis.Medical science monitor : international medical journal of experimental and clinical research · 2019
   Pooled it
2. Low-Dose Methotrexate for the Prevention of Atherosclerotic Events.The New England journal of medicine · 2019
   Trial
3. Mechanism of HJ11 Decoction in the Treatment of Atherosclerosis Based on Network Pharmacology and Experimental Validation.Combinatorial chemistry & high throughput screening · 2025
   Article
4. Assessment of total carotid plaque area progression in patients with chronic kidney disease. Good practices for decision-making.Journal of nephrology · 2025
   Article
5. Non-alcoholic fatty liver disease and heart failure: A comprehensive bioinformatics and Mendelian randomization analysis.ESC heart failure · 2024
   Article
6. Functions of TAM Receptors and Ligands Protein S and Gas6 in Atherosclerosis and Cardiovascular Disease.International journal of molecular sciences · 2024
   Review
7. Targeting endothelial vascular cell adhesion molecule-1 in atherosclerosis: drug discovery and development of vascular cell adhesion molecule-1-directed novel therapeutics.Cardiovascular research · 2023
   Review
8. Recent Advances in Anti-Atherosclerosis and Potential Therapeutic Targets for Nanomaterial-Derived Drug Formulations.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023
   Review
9. Endogenous IL-1 receptor antagonist restricts healthy and malignant myeloproliferation.Nature communications · 2023
   Article
10. Interleukin-1β suppression dampens inflammatory leucocyte production and uptake in atherosclerosis.Cardiovascular research · 2022
    Article
11. Potential of Phage Display Antibody Technology for Cardiovascular Disease Immunotherapy.Journal of cardiovascular translational research · 2022
    Review
12. Elevated HsCRP in Chronic Obstructive Pulmonary Disease: A Prospective Study of Long-Term Outcomes After Percutaneous Coronary Intervention.International journal of chronic obstructive pulmonary disease · 2022
    Article
13. Mechanisms of Post-critical Illness Cardiovascular Disease.Frontiers in cardiovascular medicine · 2022
    Review
14. Interplay Between Reactive Oxygen/Reactive Nitrogen Species and Metabolism in Vascular Biology and Disease.Antioxidants & redox signaling · 2021
    Review
15. MicroRNA-302c-3p inhibits endothelial cell pyroptosis via directly targeting NOD-, LRR- and pyrin domain-containing protein 3 in atherosclerosis.Journal of cellular and molecular medicine · 2021
    Article
16. The association between lipid levels and leukocyte count: A cross-sectional and longitudinal analysis of three large cohorts.American heart journal plus : cardiology research and practice · 2021
    Article
17. Beyond Self-Recycling: Cell-Specific Role of Autophagy in Atherosclerosis.Cells · 2021
    Review
18. Exosome-mediated delivery of inflammation-responsiveTheranostics · 2021
    Article
19. Immunoinflammatory, Thrombohaemostatic, and Cardiovascular Mechanisms in COVID-19.Thrombosis and haemostasis · 2020
    Review
20. Clinical imaging of cardiovascular inflammation.The quarterly journal of nuclear medicine and molecular imaging : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of... · 2020
    Review

Corrections and comments

• Comment on
  Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease.2017

Authors and funding

2 authors.

Funding

No grant is acknowledged in the PubMed record.

Abstract

PubMed holds no abstract for this paper.

Indexed as