ArticleAmerican journal of physiology. Gastrointestinal and liver physiology2018
Diurnal variations in intestinal barrier integrity and liver pathology in mice: implications for alcohol binge.
Article in American journal of physiology. Gastrointestinal and liver physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 25 citations in OpenAlex.
- Determinants of enteric hyperoxaluria in the SAMP1/YitFc mouse model of spontaneous ileitis.Gut microbes · 2026Article
- Timing matters: circadian rhythm disruption in alcohol-associated peripheral organ pathophysiology.Function (Oxford, England) · 2026Review
- Circadian Rhythms in Gastroenterology: The Biological Clock's Impact on Gut Health.Gastroenterology · 2025Review
- The circadian rhythm as therapeutic target in inflammatory bowel disease.Journal of the Canadian Association of Gastroenterology · 2025Article
- Disruption of the intestinal clock drives dysbiosis and impaired barrier function in colorectal cancer.Science advances · 2024Article
- Effect of Alcohol on Clock Synchrony and Tissue Circadian Homeostasis in Mice.Molecular nutrition & food research · 2024Article
- Challenges in IBD Research 2024: Preclinical Human IBD Mechanisms.Inflammatory bowel diseases · 2024Review
- Astragaloside IV ameliorate acute alcohol-induced liver injury in miceAnnals of medicine · 2023Article
- Sleep Modulates Alcohol Toxicity inInternational journal of molecular sciences · 2022Article
- Dietary Goji Shapes the Gut Microbiota to Prevent the Liver Injury Induced by Acute Alcohol Intake.Frontiers in nutrition · 2022Article
- Integrative Analysis of Metabolome and Microbiome in Patients with Progressive Alcohol-Associated Liver Disease.Metabolites · 2021Article
- Significance of gut microbiota in alcoholic and non-alcoholic fatty liver diseases.World journal of gastroenterology · 2021Review
- Utilizing the gut microbiome in decompensated cirrhosis and acute-on-chronic liver failure.Nature reviews. Gastroenterology & hepatology · 2021Review
- Disrupted diurnal oscillation of gut-derived Short chain fatty acids in shift workers drinking alcohol: Possible mechanism for loss of resiliency of intestinal barrier in disrupted circadian host.Translational research : the journal of laboratory and clinical medicine · 2020Article
- Alcohol-Induced Immune Dysregulation in the Colon Is Diurnally Variable.Visceral medicine · 2020Article
- Melatonin and circadian rhythms in liver diseases: Functional roles and potential therapies.Journal of pineal research · 2020Review
- Alcohol and Liver Clock Disruption Increase Small Droplet Macrosteatosis, Alter Lipid Metabolism and Clock Gene mRNA Rhythms, and Remodel the Triglyceride Lipidome in Mouse Liver.Frontiers in physiology · 2020Article
- Alcohol Effects on Colon Epithelium are Time-Dependent.Alcoholism, clinical and experimental research · 2019Article
- Circadian rhythms: a regulator of gastrointestinal health and dysfunction.Expert review of gastroenterology & hepatology · 2019Review
- Alcohol, liver disease and the gut microbiota.Nature reviews. Gastroenterology & hepatology · 2019Review
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
Abstract
Recent studies suggest that circadian rhythms regulate intestinal barrier integrity, but it is not clear whether there are daily variations in barrier integrity. This study investigated daily variations in intestinal barrier integrity, including whether there are differences in alcohol-induced intestinal barrier dysfunction after an alcohol binge at different times of day and whether this is associated with concurrent liver injury. C57BL6/J male mice were fed a standard chow diet, an alcohol-containing liquid diet, or an alcohol control diet for 4 wk. During week 5 (i.e., on days 43-45), mice received three once-daily gavages of alcohol (6 g/kg) or the control (phosphate-buffered saline) at the same time each day. Immediately after the binge on the second day, intestinal permeability was assessed. Four hours after the third and final binge, mice were euthanized and tissue samples collected. The results demonstrated diet-specific and outcome-specific effects of time, alcohol, and/or time by alcohol interaction. Specifically, the alcohol binge robustly influenced markers of intestinal barrier integrity, and liver markers were robustly influenced by time of day. Only intestinal permeability (i.e., sucralose) demonstrated a significant effect of time and also showed a binge by time interaction, suggesting that the time of the alcohol binge influences colonic permeability. NEW & NOTEWORTHY This study investigated daily variations in intestinal barrier integrity, including whether there are differences in alcohol-induced intestinal barrier dysfunction after an alcohol binge at different times of day and whether this is associated with concurrent liver injury. We conclude that 1) alcohol binge significantly impacted markers of intestinal permeability, 2) time of day significantly affected liver outcomes, and 3) the time of day influenced colonic permeability.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.