Evidence map›Paper›PMID 29074454›Full record

ReviewThe Journal of allergy and clinical immunology2018

MicroRNA.

Thomas X Lu, Marc E Rothenberg

Registry-linked trialAbstract readReview
In one paragraph

Review in The Journal of allergy and clinical immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06469892 (Application of Salivary and Plasma Exosomes in the Diagnosis of Oral Leukoplakia Malignant Transformation and Prognosis Monitoring of Oral Cancer), which is not on this map. Cited by 1,421 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1,421citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06469892 completednot on this mapstarted 2020, after this paper: background citation

Application of Salivary and Plasma Exosomes in the Diagnosis of Oral Leukoplakia Malignant Transformation and Prognosis Monitoring of Oral Cancer

Typeobservational_patient_registrySponsorBeijing Stomatological Hospital, Capital Medical UniversityRan2020 to 2023Enrolled225ConditionsOral Leukoplakia, Oral CancerArmsDetect the expression level of miR-185 in salivary and plasma exosomes.
3 · Its place in the literature

Who cites it

1,421 citing papers in PubMed, 5 syntheses or guidelines pooled it.

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1,361 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Thomas X LuDivision of Gastroenterology, University of Chicago Medicine, Chicago, Ill.
Marc E RothenbergDivision of Allergy and Immunology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio. Electronic address: Rothenberg@cchmc.org.

Funding

Genetic and Immunological Dissection of Eosinophilic EsophagitisR01AI124355 · NIAID · CINCINNATI CHILDRENS HOSP MED CTR · PI Marc E. Rothenberg · 2015 to 2026
$5.9M
Regulation of Gastrointestinal EosinophilsR37AI045898 · NIAID · CINCINNATI CHILDRENS HOSP MED CTR · PI ROTHENBERG, MARC E. · 2010 to 2019
$3.6M
NIAID NIH HHS R01 AI124355NIAID NIH HHS R37 AI045898
6 · The paper itself

Abstract

MicroRNAs (miRNAs) are small endogenous RNAs that regulate gene-expression posttranscriptionally. MiRNA research in allergy is expanding because miRNAs are crucial regulators of gene expression and promising candidates for biomarker development. MiRNA mimics and miRNA inhibitors currently in preclinical development have shown promise as novel therapeutic agents. Multiple technological platforms have been developed for miRNA isolation, miRNA quantitation, miRNA profiling, miRNA target detection, and modulating miRNA levels in vitro and in vivo. Here we will review the major technological platforms with consideration given for the advantages and disadvantages of each platform.

Indexed as

MicroRNAsGene Expression RegulationGenetic MarkersHumansHypersensitivityIn Vitro TechniquesGenetic MarkersMicroRNAsAllergyantagomiRsantimiRsCRISPRCRISPR/Cas9gene silencingin situ hybridizationmicroarraymicroRNAmicroRNA methodsmiRNAmiRNA expressionmiRNA inhibitorsmiRNA isolationmiRNA mimicsmiRNA profilingmiRNA quantitationmiRNA targetsqPCRstem-loop

Identifiers

PMID29074454
PMCPMC5889965

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.