Evidence map›Paper›PMID 29074386›Full record

ArticleExperimental eye research2018

Unlike Th1/Th17 cells, Th2/Th9 cells selectively migrate to the limbus/conjunctiva and initiate an eosinophilic infiltration process.

Cuiyan Tan, Wambui S Wandu, Anthony St Leger, Jennifer Kielczewski, Eric F Wawrousek, Chi-Chao Chan, Igal Gery

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental eye research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Cuiyan TanLaboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD, USA.
Wambui S WanduLaboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD, USA.
Anthony St LegerLaboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD, USA.
Jennifer KielczewskiBiological Imaging Core, National Eye Institute, National Institutes of Health, Bethesda, MD, USA.
Eric F WawrousekGenetic Engineering Core, National Eye Institute, National Institutes of Health, Bethesda, MD, USA.
Chi-Chao ChanLaboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD, USA.
Igal GeryLaboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD, USA. Electronic address: geryi@nei.nih.gov.
National Institutes of Health · US

Funding

IMMUNE RESPONSES TO OCULAR ANTIGENSZ01EY000069 · NEI · NATIONAL EYE INSTITUTE · PI GERY, IGAL · 1985 to 2008
$2.7M
Intramural NIH HHS Z01 EY000069
6 · The paper itself

Abstract

In this study we compared polarized mouse T-helper (Th) lymphocytes of four populations, sensitized against an ocular antigen, for their patterns of migration and induction of inflammatory processes in recipient mouse eyes expressing the target antigen. Th1, Th2, Th9 and Th17 cells transgenically expressing T-cell receptor (TCR) specific against hen egg lysozyme (HEL) were adoptively transferred to recipient mice expressing HEL in their eyes. Recipient eyes collected 4 or 7 days post injection were analyzed for histopathological changes. Th1 and Th17 cells induced moderate to severe intraocular inflammation in the recipient mouse eyes, but essentially did not migrate into the conjunctiva. In contrast, Th2 and Th9 cells invaded minimally the intraocular space of recipient eyes, but accumulated in the limbus and migrated into the conjunctiva of the recipient mice and initiated allergy-like inflammatory responses, as indicated by remarkable eosinophil involvement. These data thus shed new light on the differences between the migration patterns and ocular pathogenic processes mediated by Th1/Th17 and by Th2/Th9 populations.

Indexed as

Cell MovementAnimalsConjunctivaDisease Models, AnimalEosinophiliaLens, CrystallineLimbus CorneaeMiceMuramidaseTh17 CellsTh1 CellsTh2 CellsT-Lymphocytes, Helper-Inducerhen egg lysozymeMuramidase

Identifiers

PMID29074386
PMCPMC5756512
OpenAlexW2766899489

What OpenQuestion holds

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LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.