ArticleBrain, behavior, and immunity2018
Anti gliadin antibodies (AGA IgG) related to peripheral inflammation in schizophrenia.
Article in Brain, behavior, and immunity, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.
- Psychiatric Manifestations of Coeliac Disease, a Systematic Review and Meta-Analysis.Nutrients · 2020Pooled it
- Randomized double-blind inpatient study of a gluten-free diet for negative symptoms in people with schizophrenia.Schizophrenia research · 2026Trial
- Pilot study indicates that a gluten-free diet lowers oxidative stress for gluten-sensitive persons with schizophrenia.Schizophrenia research · 2024Trial
- Randomized controlled trial of a gluten-free diet in patients with schizophrenia positive for antigliadin antibodies (AGA IgG): a pilot feasibility studyJournal of psychiatry & neuroscience : JPN · 2019Trial
- The Effects of a Gluten-Free Diet on Immune Markers and Kynurenic Acid Pathway Metabolites in Patients With Schizophrenia Positive for Antigliadin Antibodies Immunoglobulin G.Journal of clinical psychopharmacologyTrial
- T cells are associated with negative symptoms in persons with anti-gliadin antibody positive schizophrenia and related disorders.Schizophrenia research · 2025Article
- Autoantibodies and Inflammation in Schizophrenia.Psychiatry and clinical neurosciences · 2025Review
- Measuring oxidative stress by the iridium reducing capacity assay (Ir-RCA).Advances in redox research · 2025Article
- Review
- Sex differences in abnormal gluten response and predictors of gluten sensitivity in patients with schizophrenia.Frontiers in immunology · 2025Article
- Review
- The Prevalence of Anxiety and Depressive Symptoms Among Patients With Celiac Disease in Jordan.Cureus · 2023Article
- The relationship of peripheral inflammation with antibodies to gliadin (AGA IgG) in persons with schizophrenia.Schizophrenia research · 2023Article
- Immunologic profiling in schizophrenia and rheumatoid arthritis.Psychiatry research · 2022Article
- Nutritional psychiatry in the treatment of psychotic disorders: Current hypotheses and research challenges.Brain, behavior, & immunity - health · 2020Article
- From Infection to the Microbiome: An Evolving Role of Microbes in Schizophrenia.Current topics in behavioral neurosciences · 2020Review
- Neuroinflammation and Schizophrenia.Current psychiatry reports · 2019Review
- Gut permeability and mimicry of the Glutamate Ionotropic Receptor NMDA type Subunit Associated with protein 1 (GRINA) as potential mechanisms related to a subgroup of people with schizophrenia with elevated antigliadin antibodies (AGA IgG).Schizophrenia research · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 1 country.
Funding
Abstract
Altered immune function and inflammation are seen in schizophrenia, however, peripheral inflammatory markers are not consistently elevated in all people, suggesting inflammation may be present only in a subgroup. We measured TNF-α and IL-Iβ in 100 people with schizophrenia or schizoaffective disorder and correlated these with antibodies to gliadin, a protein found in wheat, barley and rye that has been found to be elevated in some people with schizophrenia. We hypothesized that higher peripheral antigliadin antibodies (AGA IgG) would be associated with higher peripheral inflammation as measured by TNF-α and IL-1β. Mean log transformed values of TNF-α, (p=.029) and IL-1β (p=.016) were over twofold higher in people with schizophrenia who had high levels of AGA IgG (≥7 U) compared to those who did not have positivity to AGA IgG. We found a significant positive correlation between AGA IgG and the log transformed TNF-α (r=0.42, p<.0001) as well as IL-Iβ (r=0.51, p<.0001). The relationship was independent of cigarette smoking, body mass index and antipsychotic medications. People with schizophrenia having higher levels of AGA IgG show higher levels of peripheral inflammation and may define a subgroup with distinct pathophysiology and potentially novel treatment targets.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.