ArticleNeuromuscular disorders : NMD2017
International Workshop:: Outcome measures and clinical trial readiness in primary mitochondrial myopathies in children and adults. Consensus recommendations. 16-18 November 2016, Rome, Italy.
2 registry-linked trialsOpen access · bronzeAbstract readConsensus Statement
In one paragraph
Article in Neuromuscular disorders : NMD, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 47 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed, 1 pooled it
6.2field-weighted citation impact, top 3% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Open Label Pilot Study Using Hydroxytyrosol (HT) as a Dietary Supplement in Patients With Mitochondrial Diseases (MDs)
Global Mitochondrial Registry to Define Natural History and Outcome Measures to Achieve Definite Trial Readiness for Mitochondrial Disorders
Who cites it
47 citing papers in PubMed, 1 synthesis or guideline pooled it, 126 citations in OpenAlex.
- Quantitative assessment of efficacy and evaluation of feasibility of exercise training protocols in adult and pediatric primary mitochondrial disease.BMC medicine · 2026Pooled it
- Genotype-specific effects of elamipretide in patients with primary mitochondrial myopathy: a post hoc analysis of the MMPOWER-3 trial.Orphanet journal of rare diseases · 2024Trial
- Efficacy and Safety of Elamipretide in Individuals With Primary Mitochondrial Myopathy: The MMPOWER-3 Randomized Clinical Trial.Neurology · 2023Trial
- Trial
- A randomized crossover trial of elamipretide in adults with primary mitochondrial myopathy.Journal of cachexia, sarcopenia and muscle · 2020Trial
- Mavodelpar in patients with primary mitochondrial myopathy: a phase 1 trial.Scientific reports · 2026Article
- Effects of exercise training on skeletal muscle function in patients with mitochondrial myopathy: a systematic review.Frontiers in sports and active living · 2026Review
- Urinary Multi-Omics Profiling Reveals Systemic Molecular Alterations in Progressive External Ophthalmoplegia.International journal of molecular sciences · 2025Article
- Mitochondrial cardiomyopathy with skeletal muscle myopathy caused by m.3260A > G mutation in MT-TL1 gene: a case report.Journal of medical case reports · 2025Article
- Accelerate the discovery of genetic variants in mitochondrial diseases with Variant prIOritization using Latent spAce.Briefings in bioinformatics · 2025Article
- Ophthalmological signs and sensorimotor evaluation in mitochondrial chronic progressive external ophthalmoplegia: a multidisciplinary prospective study.BMC ophthalmology · 2025Article
- Open-label pilot study using hydroxytyrosol as dietary supplements in patients with mitochondrial diseases.Orphanet journal of rare diseases · 2025Article
- The most bothersome symptoms in neuromuscular diseases: the ERN EURO NMD Survey.Orphanet journal of rare diseases · 2025Article
- GDF15 Neutralization Ameliorates Muscle Atrophy and Exercise Intolerance in a Mouse Model of Mitochondrial Myopathy.Journal of cachexia, sarcopenia and muscle · 2025Article
- The profound implications of mitochondrial myopathy on activities of daily living: an observational qualitative study of standardized structured and semi-structured patient interviews.Therapeutic advances in chronic disease · 2025Article
- Resolving Phenotypic Variability in Mitochondrial Diseases: Preliminary Findings of a Proteomic Approach.International journal of molecular sciences · 2024Article
- Management of seizures in patients with primary mitochondrial diseases: consensus statement from the InterERNs Mitochondrial Working Group.European journal of neurology · 2024Article
- Mitochondrial myopathy without extraocular muscle involvement: a unique clinicopathologic profile.Journal of neurology · 2024Article
- Characterization of Fatigue in Primary Mitochondrial Myopathies: Findings From a Qualitative Interview Study.Neurology. Clinical practice · 2024Article
- A clinical approach to diagnosis and management of mitochondrial myopathies.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 20 institutions in 9 countries.
Michelangelo MancusoDepartment of Experimental and Clinical Medicine, Neurological Institute, University of Pisa, Italy. Electronic address: mancusomichelangelo@gmail.com.
Robert McFarlandWellcome Trust Centre for Mitochondrial Research, Institute of Genetic Medicine, Department of Physiology and Functional Genomics NE1 3BZ, Newcastle University, Newcastle upon Tyne, UK.
Thomas KlopstockFriedrich-Baur-Institut an der Neurologischen Klinik und Poliklinik, LMU München, Ziemssenstr. 1a, 80336 München, Federal Republic of Germany.
Michio HiranoDepartment of Neurology, H. Houston Merritt Neuromuscular Research Center, Columbia University Medical Center, New York, NY, USA.
consortium on Trial Readiness in Mitochondrial Myopathies
Wellcome Centre for Mitochondrial Research · GBColumbia University Irving Medical Center · USUniversity of Pisa · ITAsociación Española de Urología · ESCharité - Universitätsmedizin Berlin · DEFondazione IRCCS Istituto Neurologico Carlo Besta · ITFriedrich Baur Stiftung · DEHaukeland University Hospital · NOInstitut de Recerca Sant Joan de DéuIstituti di Ricovero e Cura a Carattere Scientifico · ITKurume University · JPLudwig-Maximilians-Universität München · DEMRC Mitochondrial Biology Unit · GBNational Center for Advancing Translational Sciences · USNewcastle University · GBRadboud Institute for Molecular Life Sciences · NLRadboud University Nijmegen · NLTechnical University of Munich · DEUnited Mitochondrial Disease Foundation · USUniversidad de Zaragoza · ES
Funding
The North American Mitochondrial Disease Consortium (NAMDC)U54NS078059 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI VAN HOVE, JOHAN L · 2011 to 2023
$17.5MTech-CoreP01HD080642 · NICHD · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI DIMAURO, SALVATORE, HIRANO, MICHIO · 2014 to 2018
$7.8M3.0T Magnetic Resonance Imaging System for Preclinical, Translational and Clinical ResearchS10OD021782 · OD · WEILL MEDICAL COLL OF CORNELL UNIV · PI WANG, YI · 2016 to 2016
$2.0MMedical Research Council MC_UP_1002/1Medical Research Council MC_UU_00015/5Medical Research Council MC_UU_00015/8Medical Research Council MR/N025431/1NICHD NIH HHS P01 HD080642NIH HHS S10 OD021782NINDS NIH HHS U54 NS078059Wellcome Trust
Abstract
PubMed holds no abstract for this paper.
Indexed as
Outcome Assessment, Health CareAdultChildClinical Trials as TopicCongresses as TopicHumansItalyMitochondrial Myopathies
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
NCT04543968ClinicalTrials.gov
NCT05554835ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.