Evidence map›Paper›PMID 29074273›Full record

ArticleUltrasound in medicine & biology2018

Real-Time Spatiotemporal Control of High-Intensity Focused Ultrasound Thermal Ablation Using Echo Decorrelation Imaging in ex Vivo Bovine Liver.

Mohamed A Abbass, Jakob K Killin, Neeraja Mahalingam, Fong Ming Hooi, Peter G Barthe, T Douglas Mast

Abstract read
In one paragraph

Article in Ultrasound in medicine & biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Optimized Echo Decorrelation Imaging Feedback for Bulk Ultrasound Ablation Control.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Mohamed A AbbassBiomedical Engineering, University of Cincinnati, Cincinnati, Ohio, USA.
Jakob K KillinBiomedical Engineering, University of Cincinnati, Cincinnati, Ohio, USA.
Neeraja MahalingamBiomedical Engineering, University of Cincinnati, Cincinnati, Ohio, USA.
Fong Ming HooiUltrasound Division, Siemens Healthcare, Issaquah, Washington, USA.
Peter G BartheGuided Therapy Systems/Ardent Sound, Mesa, Arizona, USA.
T Douglas MastBiomedical Engineering, University of Cincinnati, Cincinnati, Ohio, USA. Electronic address: doug.mast@uc.edu.

Funding

Real-time prediction of thermal ablation-induced cell death by echo decorrelationR01CA158439 · NCI · UNIVERSITY OF CINCINNATI · PI MAST, T DOUGLAS · 2012 to 2022
$3.4M
NCI NIH HHS R01 CA158439
6 · The paper itself

Abstract

The ability to control high-intensity focused ultrasound (HIFU) thermal ablation using echo decorrelation imaging feedback was evaluated in ex vivo bovine liver. Sonications were automatically ceased when the minimum cumulative echo decorrelation within the region of interest exceeded an ablation control threshold, determined from preliminary experiments as -2.7 (log-scaled decorrelation per millisecond), corresponding to 90% specificity for local ablation prediction. Controlled HIFU thermal ablation experiments were compared with uncontrolled experiments employing two, five or nine sonication cycles. Means and standard errors of the lesion width, area and depth, as well as receiver operating characteristic curves testing ablation prediction performance, were computed for each group. Controlled trials exhibited significantly smaller average lesion area, width and treatment time than five-cycle or nine-cycle uncontrolled trials and also had significantly greater prediction capability than two-cycle uncontrolled trials. These results suggest echo decorrelation imaging is an effective approach to real-time HIFU ablation control.

Indexed as

AnimalsCattleHigh-Intensity Focused Ultrasound AblationImage Interpretation, Computer-AssistedLiverEcho decorrelation imagingHigh-intensity focused ultrasoundReal-time controlThermal ablation

Identifiers

PMID29074273
PMCPMC5712268

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.