ArticleComparative biochemistry and physiology. Toxicology & pharmacology : CBP2018
Rattling the border wall: Pathophysiological implications of functional and proteomic venom variation between Mexican and US subspecies of the desert rattlesnake Crotalus scutulatus.
Article in Comparative biochemistry and physiology. Toxicology & pharmacology : CBP, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 43 citations in OpenAlex.
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- Differential Antivenom and Small-Molecule Inhibition of Novel Coagulotoxic Variations inToxins · 2022Article
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- A symphony of destruction: Dynamic differential fibrinogenolytic toxicity by rattlesnake (Crotalus and Sistrurus) venoms.Comparative biochemistry and physiology. Toxicology & pharmacology : CBP · 2021Article
- Widespread and Differential Neurotoxicity in Venoms from the Bitis Genus of Viperid Snakes.Neurotoxicity research · 2021Article
- The Relative Efficacy of Chemically Diverse Small-Molecule Enzyme-Inhibitors Against Anticoagulant Activities of African Spitting Cobra (Frontiers in immunology · 2021Article
- A Clot Twist: Extreme Variation in Coagulotoxicity Mechanisms in Mexican Neotropical Rattlesnake Venoms.Frontiers in immunology · 2021Article
- Functional Mining of theMolecules (Basel, Switzerland) · 2020Article
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- Detection and quantification of a β-neurotoxin (crotoxin homologs) in the venom of the rattlesnakesToxicon: X · 2019Article
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Authors and funding
16 authors at 8 institutions in 3 countries.
Funding
Abstract
While some US populations of the Mohave rattlesnake (Crotalus scutulatus scutulatus) are infamous for being potently neurotoxic, the Mexican subspecies C. s. salvini (Huamantlan rattlesnake) has been largely unstudied beyond crude lethality testing upon mice. In this study we show that at least some populations of this snake are as potently neurotoxic as its northern cousin. Testing of the Mexican antivenom Antivipmyn showed a complete lack of neutralisation for the neurotoxic effects of C. s. salvini venom, while the neurotoxic effects of the US subspecies C. s. scutulatus were time-delayed but ultimately not eliminated. These results document unrecognised potent neurological effects of a Mexican snake and highlight the medical importance of this subspecies, a finding augmented by the ineffectiveness of the Antivipmyn antivenom. These results also influence our understanding of the venom evolution of Crotalus scutulatus, suggesting that neurotoxicity is the ancestral feature of this species, with the US populations which lack neurotoxicity being derived states.
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