Evidence map›Paper›PMID 29074250›Full record

ArticleCellular immunology2017

ESC-derived thymic epithelial cells expressing MOG prevents EAE by central and peripheral tolerance mechanisms.

Min Su, Yujun Lin, Cheng Cui, Xiaohong Tian, Xiuling Lu, Zhixu He, Laijun Lai

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cellular immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Min SuDepartment of Allied Health Sciences, University of Connecticut, Storrs, CT, USA; Tissue Engineering and Stem Cell Research Center, School of Basic Medical Sciences, Guizhou Medical University, Guizhou, China.
Yujun LinDepartment of Allied Health Sciences, University of Connecticut, Storrs, CT, USA.
Cheng CuiDepartment of Allied Health Sciences, University of Connecticut, Storrs, CT, USA.
Xiaohong TianDepartment of Allied Health Sciences, University of Connecticut, Storrs, CT, USA.
Xiuling LuDepartment of Pharmaceutical Sciences, University of Connecticut, Storrs, CT, USA.
Zhixu HeTissue Engineering and Stem Cell Research Center, School of Basic Medical Sciences, Guizhou Medical University, Guizhou, China; Pediatric Department of the Affiliated Hospital, Guizhou Medical University, Guizhou, China. Electronic address: hzx@gmc.edu.cn.
Laijun LaiDepartment of Allied Health Sciences, University of Connecticut, Storrs, CT, USA; University of Connecticut Stem Cell Institute, University of Connecticut, Storrs, CT, USA. Electronic address: laijun.lai@uconn.edu.
University of Connecticut · USGuiyang Medical University · CN

Funding

Transplantation of ESC-derived thymic epithelial progenitors expressing autoantigen(s) ameliorating experimental autoimmune encephalomyelitisR01AI123131 · NIAID · UNIVERSITY OF CONNECTICUT STORRS · PI LAI, LAIJUN · 2016 to 2020
$1.9M
NIAID NIH HHS R01 AI123131
6 · The paper itself

Abstract

Experimental autoimmune encephalomyelitis (EAE) is an animal model for multiple sclerosis (MS), and is induced by immunization with disease-causative self-antigens such as myelin oligodendrocyte glycoprotein (MOG). We have previously reported that transplantation of MOG expressing thymic epithelial progenitors (TEPs) derived from 129S6SvEv Tac mouse embryonic stem cells (mESCs) prevented the development of EAE. In this study, we expand our previous studies to show that transplantation of MOG expressing mESC-TEPs derived from C57BL/6 mice also prevents EAE development. Furthermore, by using a MOG-specific T cell receptor (TCR) transgenic mouse model, we demonstrate that both central and peripheral tolerances are involved in the prevention of EAE induced by MOG expressing mESC-TEPs. Our results suggest that transplantation of human ESC-TEPs expressing MOG may provide an effective approach for the induction of MOG-specific immune tolerance, thereby the prevention and treatment of MS.

Indexed as

AnimalsDisease Models, AnimalEmbryonic Stem CellsEncephalomyelitis, Autoimmune, ExperimentalEpithelial CellsHumansImmune ToleranceMiceMice, Inbred C57BLMice, TransgenicMultiple SclerosisMyelin-Oligodendrocyte GlycoproteinReceptors, Antigen, T-CellThymus GlandMog protein, mouseMyelin-Oligodendrocyte GlycoproteinReceptors, Antigen, T-CellEmbryonic stem cellsExperimental autoimmune encephalomyelitisMultiple sclerosisT cellsThymic epithelial cellsTolerance induction

Identifiers

PMID29074250
PMCPMC5733639
OpenAlexW2766497753

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.