Evidence map›Paper›PMID 29074193›Full record

ArticlePapillomavirus research (Amsterdam, Netherlands)2016

Prevalence and risk factors associated with high-grade anal squamous intraepithelial lesions (HSIL)-AIN2 and HSIL-AIN3 in homosexual men.

Dorothy A Machalek, Fengyi Jin, I Mary Poynten, Richard J Hillman, David J Templeton, Carmella Law, Jennifer M Roberts, Sepehr N Tabrizi, Suzanne M Garland, Annabelle Farnsworth and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Papillomavirus research (Amsterdam, Netherlands), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 39 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. Article
  6. Impact of a Gender-Neutral HPV Vaccination Program in Men Who Have Sex with Men (MSM).International journal of environmental research and public health · 2021
    Article
  7. Article
  8. Article
  9. Article
  10. Prevalence of and Risk Factors for Anal High-grade Squamous Intraepithelial Lesions in Women Living with Human Immunodeficiency Virus.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2020
    Article
  11. Review
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 9 institutions in 1 country.

Dorothy A MachalekHIV Epidemiology and Prevention Program, The Kirby Institute for infection and immunity in society, University of New South Wales, Sydney, Australia; Department of Microbiology and Infectious Diseases, Royal Women's Hospital and Murdoch Childrens Research Institute, Melbourne, Australia.
Fengyi JinHIV Epidemiology and Prevention Program, The Kirby Institute for infection and immunity in society, University of New South Wales, Sydney, Australia.
I Mary PoyntenHIV Epidemiology and Prevention Program, The Kirby Institute for infection and immunity in society, University of New South Wales, Sydney, Australia.
Richard J HillmanWestern Sydney Sexual Health Centre, Western Sydney Local Health District, Parramatta, New South Wales 2137, Australia; Centre for Infectious Diseases and Microbiology, Westmead Clinical School, University of Sydney, New South Wales 2006, Australia; St Vincent's Hospital, Sydney, New South Wales, Australia.
David J TempletonHIV Epidemiology and Prevention Program, The Kirby Institute for infection and immunity in society, University of New South Wales, Sydney, Australia; RPA Sexual Health, Sydney Local Health District, Sydney, Australia.
Carmella LawSt Vincent's Hospital, Sydney, New South Wales, Australia.
Jennifer M RobertsDouglass Hanly Moir Pathology, Sydney, New South Wales, Australia.
Sepehr N TabriziDepartment of Microbiology and Infectious Diseases, Royal Women's Hospital and Murdoch Childrens Research Institute, Melbourne, Australia; Department of Obstetrics and Gynaecology, University of Melbourne, Parkville, Victoria, Australia.
Suzanne M GarlandDepartment of Microbiology and Infectious Diseases, Royal Women's Hospital and Murdoch Childrens Research Institute, Melbourne, Australia; Department of Obstetrics and Gynaecology, University of Melbourne, Parkville, Victoria, Australia.
Annabelle FarnsworthDouglass Hanly Moir Pathology, Sydney, New South Wales, Australia.
Christopher K FairleyMelbourne Sexual Health Centre, Carlton, Victoria, Australia and Central Clinical School Monash University, Victoria, Australia.
Andrew E GrulichHIV Epidemiology and Prevention Program, The Kirby Institute for infection and immunity in society, University of New South Wales, Sydney, Australia. Electronic address: agrulich@kirby.unsw.edu.au.
SPANC study team
UNSW Sydney · AUDouglass Hanly Moir Pathology · AUMonash University · AUMurdoch Children's Research Institute · AURoyal Women's Hospital · AUSt Vincent's Hospital Sydney · AUSydney Local Health District · AUSydney Sexual Health Centre · AUUniversity of Melbourne · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAnal intraepithelial neoplasia grade 2 (AIN2) and AIN grade 3 (AIN3) are commonly grouped together as high grade squamous intraepithelial lesions (HSIL). We assessed risk factors for HSIL-AIN2 and HSIL-AIN3 in a cohort of homosexual men.

methodsAt the baseline visit in the Study for the Prevention of Anal Cancer (SPANC), all men completed a questionnaire and underwent anal swabbing for cytology and HPV genotyping, followed by high resolution anoscopy.

resultsComposite-HSIL prevalence was 47% and 32% among 220 HIV-positive and 396 HIV-negative men, respectively. HSIL-AIN3 (37.7% versus 24.7%; p<0.001), but not HSIL-AIN2 (9.5% versus 7.6%; p=0.395) was more common in HIV-positive men. Recent receptive anal partners (p-trend=0.045), and increasing number of high-risk (HR)-HPV types (p-trend<0.001) were associated with HSIL-AIN2. Lifetime receptive partners (p-trend<0.001), HIV status (OR 1.74; 95% CI: 1.05-2.87) and HPV16 (OR 3.00; 95% CI: 1.56-5.75) were associated with HSIL-AIN3. HPV16 was the most common HR-HPV type detected in men with HSIL-AIN3, both HIV-negative (61.1%) and HIV-positive (54.9%). HPV16 was less commonly detected in men with HSIL-AIN2.

conclusionsGrouping HSIL-AIN2 and HSIL-AIN3 as HSIL may mask considerable heterogeneity in anal cancer risk. Given the strong link between HPV16 and anal cancer, men with HSIL-AIN3 and HPV16 are likely to be at greatest risk of cancer.

Indexed as

Sexual and Gender MinoritiesAnal CanalAnus NeoplasmsCytological TechniquesFemaleGenotyping TechniquesHumansMalePapillomaviridaePrevalenceProspective StudiesRisk FactorsSquamous Intraepithelial Lesions of the CervixSurveys and QuestionnairesCancer screeningHSILHuman papillomavirusRisk factorsSurrogate endpoints

Identifiers

PMID29074193
PMCPMC5886874
OpenAlexW2405049389

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.