ArticlePapillomavirus research (Amsterdam, Netherlands)2016
Human papillomavirus (HPV) perinatal transmission and risk of HPV persistence among children: Design, methods and preliminary results of the HERITAGE study.
Article in Papillomavirus research (Amsterdam, Netherlands), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it, 74 citations in OpenAlex.
- Human Papillomavirus Across the Reproductive Lifespan: An Integrative Review of Fertility, Pregnancy Outcomes, and Fertility-Sparing Management.Medicina (Kaunas, Lithuania) · 2025Pooled it
- Human Papillomavirus Persistence, Recurrence, and Incidence in Early Childhood.The Journal of infectious diseases · 2025Article
- Prevalence of oral HPV infection and genotype distribution in Iranian children during the early ages of life.Virology journal · 2025Article
- Viral Load of Human Papillomavirus (HPV) During Pregnancy and Its Association With HPV Vertical Transmission.Journal of medical virology · 2025Article
- Large Vulval Lesion During Pregnancy: A Diagnostic Challenge.Oman medical journal · 2024Article
- HPV infection and its correlation with p53 and Bcl-2 among pregnant mothers and their infants.Virus genes · 2024Article
- Analogies between HPV Behavior in Oral and Vaginal Cavity: Narrative Review on the Current Evidence in the Literature.Journal of clinical medicine · 2024Review
- Association between the Mode of Delivery and Vertical Transmission of Human Papillomavirus.Viruses · 2024Article
- Association between Human Papillomavirus 16 Viral Load in Pregnancy and Preterm Birth.Viruses · 2024Article
- Human Papillomavirus Concordance Between Parents and Their Newborn Offspring: Results From the Finnish Family Human Papillomavirus Study.The Journal of infectious diseases · 2024Article
- Prevalence of human papillomavirus in eyelid carcinoma among Koreans: a clinicopathological study.BMC ophthalmology · 2023Article
- Fine-grained mathematical modeling for cost-effectiveness evaluation of public health policies for cervical cancer, with application to a Colombian case study.BMC public health · 2023Article
- Human Papillomavirus Transmission and Persistence in Pregnant Women and Neonates.JAMA pediatrics · 2023Article
- Transmission and clearance of human papillomavirus infection in the oral cavity and its role in oropharyngeal carcinoma - A review.Reviews in medical virology · 2023Review
- Human Papillomavirus Infection during Pregnancy and Childhood: A Comprehensive Review.Microorganisms · 2022Review
- Maternal HPV-antibodies and seroconversion to HPV in children during the first 3 years of life.Scientific reports · 2022Article
- Seroprevalence of mucosal and cutaneous human papillomavirus (HPV) types among children and adolescents in the general population in Germany.BMC infectious diseases · 2022Article
- Knowledge, Perceptions and Attitudes Toward HPV Vaccination: A Survey on Parents of Girls Aged 11-18 Years Old in Greece.Frontiers in global women's health · 2022Article
- Association Between Human Papillomavirus Infection Among Pregnant Women and Preterm Birth.JAMA network open · 2021Article
- HPV-Associated Benign Squamous Cell Papillomas in the Upper Aero-Digestive Tract and Their Malignant Potential.Viruses · 2021Review
Corrections and comments
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Authors and funding
14 authors at 7 institutions in 1 country.
Funding
Abstract
Perinatal route of transmission of human papillomavirus (HPV) has been demonstrated in several small studies. We designed a large prospective cohort study (HERITAGE) to better understand perinatal HPV. The objective of this article is to present the study design and preliminary data. In the first phase of the study, we recruited 167 women in Montreal, Canada, during the first trimester of pregnancy. An additional 850 are currently being recruited in the ongoing phase. Cervicovaginal samples were obtained from mothers in the first trimester and tested for HPV DNA from 36 mucosal genotypes (and repeated in the third trimester for HPV-positive mothers). Placental samples were also taken for HPV DNA testing. Conjunctival, oral, pharyngeal and genital samples were collected for HPV DNA testing in children of HPV-positive mothers at every 3-6 months from birth until 2 years of age. Blood samples were collected in mother and children for HPV serology testing. We found a high prevalence of HPV in pregnant women (45%[95%CI:37-53%]) and in placentas (14%[8-21%]). The proportion of HPV positivity (any site) among children at birth/3-months was 11%[5-22%]. HPV was detected in children in multiple sites including the conjunctiva (5%[10-14%]). The ongoing HERITAGE cohort will help provide a better understanding of perinatal HPV.
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Registered trials
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