ArticleNMR in biomedicine2018
Hadamard editing of glutathione and macromolecule-suppressed GABA.
Article in NMR in biomedicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 17 citations in OpenAlex.
- Simultaneous edited MRS of GABA, glutathione, and ethanol.NMR in biomedicine · 2020Trial
- Brain glutathione and GABA+ levels in autistic children.Autism research : official journal of the International Society for Autism Research · 2024Article
- Severity of prematurity and age impact early postnatal development of GABA and glutamate systems.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- A comprehensive guide to MEGA-PRESS for GABA measurement.Analytical biochemistry · 2023Review
- Impact of gradient scheme and non-linear shimming on out-of-voxel echo artifacts in edited MRS.NMR in biomedicine · 2023Article
- Decreased Brain GABA Levels in Patients with Migraine Without Aura: An Exploratory Proton Magnetic Resonance Spectroscopy Study.Neuroscience · 2022Article
- Edited magnetic resonance spectroscopy in the neonatal brain.Neuroradiology · 2022Review
- Prediction learning in adults with autism and its molecular correlates.Molecular autism · 2021Article
- Spectral editing inNMR in biomedicine · 2021Article
- GSH and GABA decreases in IDH1-mutated low-grade gliomas detected by HERMES spectral editing at 3 T in vivo.Neurochemistry international · 2020Article
- Motion correction in magnetic resonance spectroscopy.Magnetic resonance in medicine · 2020Review
- Simultaneous editing of GABA and GSH with Hadamard-encoded MR spectroscopic imaging.Magnetic resonance in medicine · 2019Article
- Advanced Hadamard-encoded editing of seven low-concentration brain metabolites: Principles of HERCULES.NeuroImage · 2019Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
The primary inhibitory neurotransmitter γ-aminobutyric acid (GABA) and the major antioxidant glutathione (GSH) are compounds of high importance for the function and integrity of the human brain. In this study, a method for simultaneous J-difference spectral-edited magnetic resonance spectroscopy (MRS) of GSH and GABA with suppression of macromolecular (MM) signals at 3 T is proposed. MM-suppressed Hadamard encoding and reconstruction of MEGA (Mescher-Garwood)-edited spectroscopy (HERMES) consists of four sub-experiments (TE = 80 ms), with 20-ms editing pulses applied at: (A) 4.56 and 1.9 ppm; (B) 4.56 and 1.5 ppm; (C) 1.9 ppm; and (D) 1.5 ppm. One Hadamard combination (A + B - C - D) yields GSH-edited spectra, and another (A - B + C - D) yields GABA-edited spectra, with symmetric suppression of the co-edited MM signal. MM-suppressed HERMES, conventional HERMES and separate Mescher-Garwood point-resolved spectroscopy (MEGA-PRESS) data were successfully acquired from a (33 mm)
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.