ArticleCerebrovascular diseases (Basel, Switzerland)2017
Temporal Associations between Fatigue, Depression, and Apathy after Stroke: Results of the Cognition and Affect after Stroke, a Prospective Evaluation of Risks Study.
Article in Cerebrovascular diseases (Basel, Switzerland), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02585349 (Cognition and Affect After Stroke), which is not on this map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Cognition and Affect After Stroke: a Prospective Evaluation of Risks
Who cites it
22 citing papers in PubMed, 50 citations in OpenAlex.
- ESTREL-Fatigue-association of levodopa with post-stroke fatigue.European stroke journal · 2026Trial
- Bibliometric Analysis of the Post-Stroke Depression (1985-2024).Brain and behavior · 2026Review
- Network analysis of neuropsychiatric, cognitive, and functional complications of stroke: implications for novel treatment targets.Psychiatry and clinical neurosciences · 2024Article
- A roadmap for research in post-stroke fatigue: Consensus-based core recommendations from the third Stroke Recovery and Rehabilitation Roundtable.International journal of stroke : official journal of the International Stroke Society · 2024Article
- A roadmap for research in post-stroke fatigue: Consensus-based core recommendations from the third Stroke Recovery and Rehabilitation Roundtable.Neurorehabilitation and neural repair · 2024Article
- Investigating cognitive impairment, biopsychosocial barriers, and predictors of return to daily life among older stroke survivors.Frontiers in neurology · 2024Article
- Post-stroke depression in Vietnamese patients is associated with decreased sleep quality and increased fatigue: a one-institution cross-sectional analysis.Sleep & breathing = Schlaf & Atmung · 2023Article
- Altered Resting-State Brain Activity and Functional Connectivity in Post-Stroke Apathy: An fMRI Study.Brain sciences · 2023Article
- Measurement Properties of the Dutch Multifactor Fatigue Scale in Early and Late Rehabilitation of Acquired Brain Injury in Denmark.Journal of clinical medicine · 2023Article
- No add-on effect of tDCS on fatigue and depression in chronic stroke patients: A randomized sham-controlled trial combining tDCS with computerized cognitive training.Brain and behavior · 2022Review
- Neural effective connectivity explains subjective fatigue in stroke.Brain : a journal of neurology · 2022Observational
- Numerical activities of daily living: a short version.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022Article
- Heightened effort discounting is a common feature of both apathy and fatigue.Scientific reports · 2021Article
- Numerical Activities of Daily Living - Financial: a short version.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2021Article
- Apathy after stroke: Diagnosis, mechanisms, consequences, and treatment.International journal of stroke : official journal of the International Stroke Society · 2021Review
- Cognitive and emotional symptoms in patients with first-ever mild stroke: The syndrome of hidden impairments.Journal of rehabilitation medicine · 2021Article
- Evaluation of Response Processes to the Danish Version of the Dutch Multifactor Fatigue Scale in Stroke Using the Three-Step Test-Interview.Frontiers in human neuroscience · 2021Article
- Lesions in the right Rolandic operculum are associated with self-rating affective and apathetic depressive symptoms for post-stroke patients.Scientific reports · 2020Article
- A central role for apathy in the effectiveness of interventions for cancer-related fatigue.Psycho-oncology · 2020Article
- Development and Validation of a Comprehensive Neuropsychological and Language Rehabilitation for Stroke Survivors: A Home-Based Caregiver-Delivered Intervention Program.Annals of Indian Academy of Neurology · 2020Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPoststroke fatigue (PSF) is a form of pathological fatigue that can develop after stroke and has a negative impact on functional outcome. PSF is associated with poststroke depression (PSD), which in turn shows similarities with poststroke apathy (PSA). This study aimed at disentangling the temporal associations between PSF and PSD and between PSF and PSA.
methodsA total of 250 stroke patients were included, of which 243 completed the Fatigue Severity Scale, Montgomery-Åsberg Depression Rating Scale, and Apathy Evaluation Scale at 3 months poststroke, with follow-up measurements at 6 and 12 months after initial testing. Linear mixed models and linear regressions were performed to evaluate the temporal associations between PSF and PSD, and between PSF and PSA.
resultsPSF was present in 119 patients (49%), of whom 62 patients also had PSD (26%), and 21 patients (9%) also had PSA. At baseline, PSF patients showed higher depression levels, which remained stable at follow-up. PSD patients had higher fatigue levels compared with no-PSD patients at baseline, which remained stable at follow-up. No association between apathy and fatigue was found at baseline and no interaction with time was found. Change in fatigue from baseline to 12-month follow-up was associated with change in depression and with change in apathy.
conclusionsBidirectional associations were found between PSF and PSD. In treatment and rehabilitation programs, early focus on the presence of PSD and PSF is important, since these conditions tend to persist. As there are currently more treatment options for PSD, attention for PSD is important and might also have a beneficial effect on PSF.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.