ArticlePLoS pathogens2017
Comparative genomics of geographically distant Fusarium fujikuroi isolates revealed two distinct pathotypes correlating with secondary metabolite profiles.
Article in PLoS pathogens, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed, 99 citations in OpenAlex.
- Apicidin is a key virulence determinant of Fusarium asiaticum in wheat-rice cropping systems.Science China. Life sciences · 2026Article
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- The Fusarium fujikuroi Species Complex in Korea: Taxonomic Revision, New Records, and Description of Fusarium ipomoeicola sp. nov.The plant pathology journal · 2025Article
- Novel amplified fragment length polymorphism (AFLP) markers for typing medically relevantFungal systematics and evolution · 2025Article
- Host-induced gene silencing targeting the calcineurin ofFrontiers in plant science · 2025Article
- Molecular identification and pathogenic impact ofFrontiers in microbiology · 2025Article
- Unveiling toxigenicFrontiers in plant science · 2025Article
- In silico prediction of polyketide biosynthetic gene clusters in the genomes of Hypericum-borne endophytic fungi.BMC genomics · 2024Article
- Non-ribosomal peptide synthetase (NRPS)-encoding products and their biosynthetic logics in Fusarium.Microbial cell factories · 2024Review
- Incorporation of the histone variant H2A.Z counteracts gene silencing mediated by H3K27 trimethylation in Fusarium fujikuroi.Epigenetics & chromatin · 2024Article
- Three Genes Involved in Different Signaling Pathways,Journal of fungi (Basel, Switzerland) · 2024Article
- H3K27me3 is vital for fungal development and secondary metabolite gene silencing, and substitutes for the loss of H3K9me3 in the plant pathogen Fusarium proliferatum.PLoS genetics · 2024Article
- HmbC, a Protein of the HMG Family, Participates in the Regulation of Carotenoid Biosynthesis inGenes · 2023Article
- Biosynthesis of the Isocoumarin Derivatives Fusamarins is Mediated by the PKS8 Gene Cluster in Fusarium.Chembiochem : a European journal of chemical biology · 2023Article
- Identification and Characterization ofPlants (Basel, Switzerland) · 2023Article
- Review
- Past and Future Epidemiological Perspectives and Integrated Management of Rice Bakanae in Korea.The plant pathology journal · 2023Review
- An explanation of the mystifying bakanae disease narrative for tomorrow's rice.Frontiers in microbiology · 2023Review
- Characterization of Host-Specific Genes from Pine- and Grass-Associated Species of thePathogens (Basel, Switzerland) · 2022Article
- Article
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Authors and funding
16 authors at 7 institutions in 5 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fusarium fujikuroi causes bakanae ("foolish seedling") disease of rice which is characterized by hyper-elongation of seedlings resulting from production of gibberellic acids (GAs) by the fungus. This plant pathogen is also known for production of harmful mycotoxins, such as fusarins, fusaric acid, apicidin F and beauvericin. Recently, we generated the first de novo genome sequence of F. fujikuroi strain IMI 58289 combined with extensive transcriptional, epigenetic, proteomic and chemical product analyses. GA production was shown to provide a selective advantage during infection of the preferred host plant rice. Here, we provide genome sequences of eight additional F. fujikuroi isolates from distant geographic regions. The isolates differ in the size of chromosomes, most likely due to variability of subtelomeric regions, the type of asexual spores (microconidia and/or macroconidia), and the number and expression of secondary metabolite gene clusters. Whilst most of the isolates caused the typical bakanae symptoms, one isolate, B14, caused stunting and early withering of infected seedlings. In contrast to the other isolates, B14 produced no GAs but high amounts of fumonisins during infection on rice. Furthermore, it differed from the other isolates by the presence of three additional polyketide synthase (PKS) genes (PKS40, PKS43, PKS51) and the absence of the F. fujikuroi-specific apicidin F (NRPS31) gene cluster. Analysis of additional field isolates confirmed the strong correlation between the pathotype (bakanae or stunting/withering), and the ability to produce either GAs or fumonisins. Deletion of the fumonisin and fusaric acid-specific PKS genes in B14 reduced the stunting/withering symptoms, whereas deletion of the PKS51 gene resulted in elevated symptom development. Phylogenetic analyses revealed two subclades of F. fujikuroi strains according to their pathotype and secondary metabolite profiles.
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