Observational studyPloS one2017
Development and validation of immune dysfunction score to predict 28-day mortality of sepsis patients.
Observational study in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04396522 (Application of Serial Body Composition Change for Risk Prediction in Treating Patients With Severe Pneumonia), which is not on this map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Application of Serial Body Composition Change for Risk Prediction in Treating Patients With Severe Pneumonia
Who cites it
29 citing papers in PubMed, 39 citations in OpenAlex.
- Using Body Composition Analysis for Improved Nutritional Intervention in Septic Patients: A Prospective Interventional Study.Nutrients · 2023Trial
- Identification of immune status subtypes and prognostic analysis of septic patients based on Th1/Th2 cytokine assays.Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2026Article
- Interferon-gamma to interleukin-10 ratio is negatively associated with short-term mortality risk in sepsis patients: a retrospective study based on immune balance index.Frontiers in immunology · 2026Article
- Leptin and Iinterlukin-6 relationship and influence of mortality in sepsis.BMC infectious diseases · 2025Article
- IL-10 to lymphocyte ratio (ILR) and lactate in the prognosis prediction and risk stratification of sepsis: a pilot study.Frontiers in medicine · 2025Article
- Enhancing prognostic accuracy in sepsis: a modified SOFA score incorporating lymphocyte count as an immune function marker.Frontiers in cellular and infection microbiology · 2025Article
- The importance of high total body water/fat free mass ratio and serial changes in body composition for predicting hospital mortality in patients with severe pneumonia: a prospective cohort study.BMC pulmonary medicine · 2024Article
- Development and validation of an interpretable model for predicting sepsis mortality across care settings.Scientific reports · 2024Article
- Article
- Ex Vivo Endotoxin Stimulation of Blood for Predicting Survival in Patients With Sepsis: A Systematic Review.CHEST critical care · 2023Article
- Persistently Elevated Soluble Triggering Receptor Expressed on Myeloid Cells 1 and Decreased Monocyte Human Leucocyte Antigen DR Expression Are Associated With Nosocomial Infections in Septic Shock Patients.Critical care explorations · 2023Article
- Association of Hypernatremia with Immune Profiles and Clinical Outcomes in Adult Intensive Care Unit Patients with Sepsis.Biomedicines · 2022Article
- A stratification strategy to predict secondary infection in critical illness-induced immune dysfunction: the REALIST score.Annals of intensive care · 2022Article
- Dynamic monitoring of kidney injury status over 3 days in the intensive care unit as a sepsis phenotype associated with hospital mortality and hyperinflammation.Biomedical journal · 2022Article
- The Survival of Septic Patients with Compensated Liver Cirrhosis Is Not Inferior to That of Septic Patients without Liver Cirrhosis: A Propensity Score Matching Analysis.Journal of clinical medicine · 2022Article
- Hematological Ratios Are Associated with Acute Kidney Injury and Mortality in Patients That Present with Suspected Infection at the Emergency Department.Journal of clinical medicine · 2022Article
- The Childhood Acute Illness and Nutrition (CHAIN) network nested case-cohort study protocol: a multi-omics approach to understanding mortality among children in sub-Saharan Africa and South Asia.Gates open research · 2022Article
- Clinical Impact of Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor AssociatedOncoTargets and therapy · 2022Article
- Immunomonitoring of Monocyte and Neutrophil Function in Critically Ill Patients: From Sepsis and/or Trauma to COVID-19.Journal of clinical medicine · 2021Review
- Application of Peak Glucose Range and Diabetes Status in Mortality Risk Stratification in Critically Ill Patients with Sepsis.Diagnostics (Basel, Switzerland) · 2021Article
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSepsis-induced immune dysfunction ranging from cytokines storm to immunoparalysis impacts outcomes. Monitoring immune dysfunction enables better risk stratification and mortality prediction and is mandatory before widely application of immunoadjuvant therapies. We aimed to develop and validate a scoring system according to patients' immune dysfunction status for 28-day mortality prediction.
methodsA prospective observational study from a cohort of adult sepsis patients admitted to ICU between August 2013 and June 2016 at Kaohsiung Chang Gung Memorial Hospital in Taiwan. We evaluated immune dysfunction status through measurement of baseline plasma Cytokine levels, Monocyte human leukocyte-DR expression by flow cytometry, and stimulated immune response using post LPS stimulated cytokine elevation ratio. An immune dysfunction score was created for 28-day mortality prediction and was validated.
resultsA total of 151 patients were enrolled. Data of the first consecutive 106 septic patients comprised the training cohort, and of other 45 patients comprised the validation cohort. Among the 106 patients, 21 died and 85 were still alive on day 28 after ICU admission. (mortality rate, 19.8%). Independent predictive factors revealed via multivariate logistic regression analysis included segmented neutrophil-to-monocyte ratio, granulocyte-colony stimulating factor, interleukin-10, and monocyte human leukocyte antigen-antigen D-related levels, all of which were selected to construct the score, which predicted 28-day mortality with area under the curve of 0.853 and 0.789 in the training and validation cohorts, respectively.
conclusionsThe immune dysfunction scoring system developed here included plasma granulocyte-colony stimulating factor level, interleukin-10 level, serum segmented neutrophil-to-monocyte ratio, and monocyte human leukocyte antigen-antigen D-related expression appears valid and reproducible for predicting 28-day mortality.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.