ArticlePloS one2017
Yersinia pestis strains of ancient phylogenetic branch 0.ANT are widely spread in the high-mountain plague foci of Kyrgyzstan.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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19 citing papers in PubMed, 63 citations in OpenAlex.
- An Overview of the Genetic Diversity and Epidemiological Potential ofPathogens (Basel, Switzerland) · 2026Review
- An ancient Erysipelothrix rhusiopathiae genome recovered from 1400-year-old human remains in the Northern Caucasus.Scientific reports · 2026Article
- Plagued by the Past, Pressed by the Present: A One Health Perspective onBiomedicines · 2025Review
- Whole genome sequencing of Yersinia pestis isolates from Central Asian natural plague foci revealed the role of adaptation to different hosts and environmental conditions in shaping specific genotypes.PLoS neglected tropical diseases · 2025Article
- Whole genome sequences ofMicrobiology resource announcements · 2024Article
- Towards a Comprehensive Definition of Pandemics and Strategies for Prevention: A Historical Review and Future Perspectives.Microorganisms · 2024Review
- Serological evidence of Yersinia pestis infection in rodents and carnivores in Northwestern Iran.PLoS neglected tropical diseases · 2023Article
- No evidence for persistent natural plague reservoirs in historical and modern Europe.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
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- Emergence and spread of ancestralProceedings of the National Academy of Sciences of the United States of America · 2022Article
- Yersinia pestis: the Natural History of Plague.Clinical microbiology reviews · 2020Review
- New ancient Eastern EuropeanPhilosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Article
- A genomic and historical synthesis of plague in 18th century Eurasia.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Soil salinity and aridity specify plague foci in the United States of America.Scientific reports · 2020Article
- The EnteroBase user's guide, with case studies onGenome research · 2020Article
- Phylogeography of the second plague pandemic revealed through analysis of historical Yersinia pestis genomes.Nature communications · 2019Article
- AncientProceedings of the National Academy of Sciences of the United States of America · 2019Article
- Ancient pathogen genomics as an emerging tool for infectious disease research.Nature reviews. Genetics · 2019Review
- Marmots andFrontiers in veterinary science · 2019Article
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10 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Fifty six Yersinia pestis strains, isolated over the period of more than 50 years in three high-mountain foci of Kyrgyzstan (Tien Shan, Alai, and Talas), have been characterized by means of PCR and single nucleotide polymorphism (SNP) typing methods. Seven of these strains were also characterized by means of whole genome sequencing and genome-wide SNP phylogenetic analysis. It was found that forty two strains belong to 0.ANT2, 0.ANT3 and 0.ANT5 phylogenetic branches. From these, strains of 0.ANT2 and 0.ANT3 branches were earlier detected in China only, whereas 0.ANT5 phylogenetic branch was identified for Y. pestis phylogeny for the first time. According to the results of genome-wide SNP analysis, 0.ANT5 strains are ones of the most closely related to Y. pestis strain responsible for the Justinianic Plague. We have also found out that four of the studied strains belong to the phylogenetic branch 2.MED1, and ten strains from Talas high-mountain focus belong to the phylogenetic branch 0.PE4 (sub-branch 0.PE4t). Established diversity of Y. pestis strains and extensive dissemination of the strains pertaining to the 0.ANT branch confirm the antiquity of the mentioned above plague foci and suggest that strains of the 0.ANT branch, which serve as precursors for all highly virulent Y. pestis strains, had their origin in the Tien Shan mountains.
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