Evidence map›Paper›PMID 29073241›Full record

ArticlePloS one2017

Detection of trace concentrations of S-nitrosothiols by means of a capacitive sensor.

James M Seckler, Nikki M Meyer, Spencer T Burton, James N Bates, Benjamin Gaston, Stephen J Lewis

Abstract read
In one paragraph

Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Article
  2. Red light mediates the exocytosis of vasodilatory vesicles from cultured endothelial cells: a cellular, and ex vivo murine model.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2024
    Article
  3. Article
  4. Article
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  6. Article
  7. Article
  8. Review
  9. Article
  10. Photolytic Measurement of TissueMolecules (Basel, Switzerland) · 2022
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Cyclic compression increases F508 Del CFTR expression in ciliated human airway epithelium.American journal of physiology. Lung cellular and molecular physiology · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

James M SecklerDepartment of Pediatrics, Case Western Reserve University, Cleveland, Ohio, United States of America.
Nikki M MeyerDepartment of Pediatrics, Case Western Reserve University, Cleveland, Ohio, United States of America.
Spencer T BurtonDepartment of Pediatrics, Case Western Reserve University, Cleveland, Ohio, United States of America.
James N BatesDepartment of Anesthesia, University of Iowa, Iowa City, Iowa, United States of America.
Benjamin GastonDepartment of Pediatrics, Case Western Reserve University, Cleveland, Ohio, United States of America.
Stephen J LewisDepartment of Pediatrics, Case Western Reserve University, Cleveland, Ohio, United States of America.ORCID http://orcid.org/0000-0001-7050-0666

Funding

Project 3 - Personalized cystic fibrosis treatment strategies with synergistic therapies Identified in vitro.P01HL128192 · NHLBI · INDIANA UNIVERSITY INDIANAPOLIS · PI GASTON, BENJAMIN · 2016 to 2020
$12.2M
S-nitrosothiol signaling in pulmonary epithelial cellsP01HL101871 · NHLBI · UNIVERSITY OF VIRGINIA · PI GASTON, BENJAMIN, LEWIS, STEPHEN JOHN · 2011 to 2015
$8.7M
Pediatric Respiratory Research TrainingT32HL125245 · NHLBI · CASE WESTERN RESERVE UNIVERSITY · PI DRUMM, MITCHELL L · 2015 to 2019
$802k
NHLBI NIH HHS P01 HL101871NHLBI NIH HHS P01 HL128192NHLBI NIH HHS T32 HL125245
6 · The paper itself

Abstract

Small molecule S-nitrosothiols are a class of endogenous chemicals in the body, which have been implicated in a variety of biological functions. However, the labile nature of NO and the limits of current detection assays have made studying these molecules difficult. Here we present a method for detecting trace concentrations of S-nitrosothiols in biological fluids. Capacitive sensors when coupled to a semiconducting material represent a method for detecting trace quantities of a chemical in complex solutions. We have taken advantage of the semiconducting and chemical properties of polydopamine to construct a capacitive sensor and associated method of use, which specifically senses S-nitrosothiols in complex biological solutions.

Indexed as

DopamineHumansLimit of DetectionMass SpectrometryS-NitrosothiolsDopamineS-Nitrosothiols

Identifiers

PMID29073241
PMCPMC5658150

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.