ArticlePloS one2017
Using a whole-body 31P birdcage transmit coil and 16-element receive array for human cardiac metabolic imaging at 7T.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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28 citing papers in PubMed, 43 citations in OpenAlex.
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- Phosphorus metabolism in the brain of cognitively normal midlife individuals at risk for Alzheimer's disease.Neuroimage. Reports · 2022Article
- Dual-Tuned Lattice Balun for Multi-Nuclear MRI and MRS.IEEE transactions on medical imaging · 2022Article
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- A Preliminary Study for Reference RF Coil at 11.7 T MRI: Based on Electromagnetic Field Simulation of Hybrid-BC RF Coil According to Diameter and Length at 3.0, 7.0 and 11.7 T.Sensors (Basel, Switzerland) · 2022Article
- Increased cardiac Pi/PCr in the diabetic heart observed using phosphorus magnetic resonance spectroscopy at 7T.PloS one · 2022Article
- 7 Tesla and Beyond: Advanced Methods and Clinical Applications in Magnetic Resonance Imaging.Investigative radiology · 2021Review
- PCA denoising and Wiener deconvolution ofMagnetic resonance in medicine · 2021Article
- A 16-ChannelIEEE transactions on bio-medical engineering · 2021Article
- Feasibility ofNMR in biomedicine · 2021Article
- Quantifying the effect of dobutamine stress on myocardial Pi and pH in healthy volunteers: AMagnetic resonance in medicine · 2021Article
- 7T MR Safety.Journal of magnetic resonance imaging : JMRI · 2021Article
- RF Coil Setup forFrontiers in neurology · 2021Article
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Authors and funding
13 authors at 4 institutions in 3 countries.
Funding
Abstract
purposeCardiac phosphorus magnetic resonance spectroscopy (31P-MRS) provides unique insight into the mechanisms of heart failure. Yet, clinical applications have been hindered by the restricted sensitivity of the surface radiofrequency-coils normally used. These permit the analysis of spectra only from the interventricular septum, or large volumes of myocardium, which may not be meaningful in focal disease. Löring et al. recently presented a prototype whole-body (52 cm diameter) transmit/receive birdcage coil for 31P at 7T. We now present a new, easily-removable, whole-body 31P transmit radiofrequency-coil built into a patient-bed extension combined with a 16-element receive array for cardiac 31P-MRS. MATERIALS AND
methodsA fully-removable (55 cm diameter) birdcage transmit coil was combined with a 16-element receive array on a Magnetom 7T scanner (Siemens, Germany). Electro-magnetic field simulations and phantom tests of the setup were performed. In vivo maps of B1+, metabolite signals, and saturation-band efficiency were acquired across the torsos of eight volunteers.
resultsThe combined (volume-transmit, local receive array) setup increased signal-to-noise ratio 2.6-fold 10 cm below the array (depth of the interventricular septum) compared to using the birdcage coil in transceiver mode. The simulated coefficient of variation for B1+ of the whole-body coil across the heart was 46.7% (surface coil 129.0%); and the in vivo measured value was 38.4%. Metabolite images of 2,3-diphosphoglycerate clearly resolved the ventricular blood pools, and muscle tissue was visible in phosphocreatine (PCr) maps. Amplitude-modulated saturation bands achieved 71±4% suppression of phosphocreatine PCr in chest-wall muscles. Subjects reported they were comfortable.
conclusionThis easy-to-assemble, volume-transmit, local receive array coil combination significantly improves the homogeneity and field-of-view for metabolic imaging of the human heart at 7T.
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