ArticlePloS one2017
Increased dietary long-chain polyunsaturated fatty acids alter serum fatty acid concentrations and lower risk of urine stone formation in cats.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 30 citations in OpenAlex.
- 2bRAD-M Reveals the Characteristics of Urinary Microbiota in Overweight Patients with Urinary Tract Stones.Biomedicines · 2025Article
- Assessment of macronutrients and fat quality in cat food.Veterinary research communications · 2025Article
- Effect of the plasma metabolites, biomarkers, and inflammatory proteins on urolithiasis: insights from Mendelian randomization and mediation analysis.Urolithiasis · 2025Article
- Metabolomic profiling of serum alterations and biomarker discovery in feline hepatic liposis.Scientific reports · 2025Article
- Associations between dietary fatty acids and kidney stones.Scientific reports · 2025Article
- Effects of algal oil as an alternative to fish oil in feline foods on serum concentrations of eicosapentaenoic acid and docosahexaenoic acid.Journal of animal science · 2025Article
- Article
- Metabolomic Changes Associated with AGXT2 Genotype Variants and Stone Formation in a Colony of Cats.Genes · 2024Article
- The balance of n-6 and n-3 fatty acids in canine, feline, and equine nutrition: exploring sources and the significance of alpha-linolenic acid.Journal of animal science · 2024Review
- Comparison of two software programs used to determine the relative supersaturation of urine ions.Frontiers in veterinary science · 2023Article
- Relative supersaturation values distinguish between feline urinary and non-urinary foods and align with expected urine analytes contributions to uroliths.Frontiers in veterinary science · 2023Article
- Dietary Betaine Interacts with Very Long Chain n-3 Polyunsaturated Fatty Acids to Influence Fat Metabolism and Circulating Single Carbon Status in the Cat.Animals : an open access journal from MDPI · 2022Article
- Dietary Ground Flaxseed Increases Serum Alpha-Linolenic Acid Concentrations in Adult Cats.Animals : an open access journal from MDPI · 2022Article
- Metabolomic changes in cats with renal disease and calcium oxalate uroliths.Metabolomics : Official journal of the Metabolomic Society · 2022Article
- Article
- Increased Water Viscosity Enhances Water Intake and Reduces Risk of Calcium Oxalate Stone Formation in Cats.Animals : an open access journal from MDPI · 2021Article
- Botanicals Reduce Circulating Concentrations of Cholesterol and Triglycerides and Work Synergistically With Arachidonic Acid to Reduce Inflammatory Cytokines in Cats.Frontiers in veterinary science · 2021Article
- Case Report: Application and Limitations of a Plant-Based Diet Formulated for a Cat With Feline Lower Urinary Tract Disease.Frontiers in veterinary science · 2021Article
- Dietary Fatty Acids Change Circulating Fatty Acids, Microbial Putrefactive Postbiotics and Betaine Status in the Cat.Animals : an open access journal from MDPI · 2020Article
- Lipidomics Reveals the Therapeutic Effects of EtOAc Extract ofFrontiers in pharmacology · 2020Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The lifespan of cats with non-obstructive kidney stones is shortened compared with healthy cats indicating a need to reduce stone formation and minimize chronic kidney disease. The purpose of this study was to investigate the effects of increasing dietary polyunsaturated fatty acids (PUFA) on urine characteristics. Domestic-short-hair cats (n = 12; mean age 5.6 years) were randomized into two groups and fed one of two dry-cat foods in a cross-over study design. For one week before study initiation, all cats consumed control food that contained 0.07% arachidonic acid (AA), but no eicosapentaenoic acid (EPA) or docosahexaenoic acid (DHA). Group 1 continued eating control food for 56 days. Group 2 was fed test food for 56 days, which was control food plus fish oil and high-AA oil. Test food contained 0.17% AA, 0.09% EPA and 0.18% DHA. After 56 days, cats were fed the opposite food for another 56 days. At baseline and after each feeding period, serum was analyzed for fatty acid concentrations, and urine for specific gravity, calcium concentration, relative-super-saturation for struvite crystals, and a calcium-oxalate-titrimetric test was performed. After consuming test food, cats had increased (all P<0.001) serum concentrations of EPA (173%), DHA (61%), and AA (35%); decreased urine specific gravity (P = 0.02); decreased urine calcium concentration (P = 0.06); decreased relative-super-saturation for struvite crystals (P = 0.03); and increased resistance to oxalate crystal formation (P = 0.06) compared with cats consuming control food. Oxalate crystal formation was correlated with serum calcium concentration (r = 0.41; P<0.01). These data show benefits for reducing urine stone formation in cats by increasing dietary PUFA.
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