Evidence map›Paper›PMID 29073217›Full record

ArticlePloS one2017

Design and synthesis of a fluorescent probe based on naphthalene anhydride and its detection of copper ions.

Guangjie He, Chenxi Liu, Xiaobo Liu, Qingzhi Wang, Aiying Fan, Songjun Wang, Xinlai Qian

Open access · goldAbstract read
In one paragraph

Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.2field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 38 citations in OpenAlex.

  1. Review
  2. A ratiometric fluorescent sensor for AlFrontiers in nutrition · 2025
    Article
  3. Novel Bis-pyrazoline Fluorescent Probe for CuJournal of fluorescence · 2024
    Article
  4. Review
  5. Review
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Guangjie HeDepartment of Forensic Medicine, Xinxiang Medical University, Xinxiang, Henan Province, P. R. China.ORCID http://orcid.org/0000-0002-4658-5214
Chenxi LiuDepartment of Forensic Medicine, Xinxiang Medical University, Xinxiang, Henan Province, P. R. China.
Xiaobo LiuDepartment of Forensic Medicine, Xinxiang Medical University, Xinxiang, Henan Province, P. R. China.
Qingzhi WangDepartment of Forensic Medicine, Xinxiang Medical University, Xinxiang, Henan Province, P. R. China.
Aiying FanDepartment of Forensic Medicine, Xinxiang Medical University, Xinxiang, Henan Province, P. R. China.
Songjun WangHebei Key Laboratory of Forensic Medicine, Hebei Medical University, Shijiazhuang, Hebei Province, P. R. China.
Xinlai QianSchool of Basic Medical Science, Xinxiang Medical University, Xinxiang, Henan Province, P. R. China.
Xinxiang Medical University · CNHebei Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Copper, as the third most abundant transition metal ions of human, plays an essential role in the redox reaction, signal transduction, hematopoiesis, and other physiological processes. Abnormal content of copper ions in the body will cause some diseases such as anemia, coronary heart disease, Menkes' syndrome. In this article, a new fluorescence probe L for Cu2+ was designed and synthetized by using 4-bromo-1,8 naphthalene anhydride and 2-thiophene formaldehyde as raw materials. Fluorescent probe L itself exhibited strong fluorescence, upon the addition of Cu2+ ions, the fluorescence was quenched. The fluorescent detection limit for Cu2+ ions was determined to be 1.8 μM based on a 3δ/S method. UV-vis absorption and fluorescence spectra indicated that probe L showed good selectivity and sensitivity for Cu2+, and this selectivity was not interfered by other metal ions and anions. Further cell fluorescence imaging experiments indicated that the probe L had potential to be used to examine copper ions in vivo.

Indexed as

Drug DesignChemistry Techniques, SyntheticCopperFluorescent DyesHydrogen-Ion ConcentrationLimit of DetectionNaphthalenesCopperFluorescent DyesnaphthaleneNaphthalenes

Identifiers

PMID29073217
PMCPMC5658116
OpenAlexW2766345180

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.