ArticlePLoS computational biology2017
Unified thalamic model generates multiple distinct oscillations with state-dependent entrainment by stimulation.
Article in PLoS computational biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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26 citing papers in PubMed.
- Awake alpha bursting emerges as the dynamic working state in a lateral geniculate thalamocortical cell model.PLoS computational biology · 2026Article
- Thalamic oscillations distinguish natural states of consciousness in humans.Nature human behaviour · 2026Article
- Histamine regulation in shaping spindle refractoriness: a computational modeling study.Journal of computational neuroscience · 2026Article
- Cortex-specific inversion of visual responses during sleep.Nature communications · 2026Article
- Tremor pathophysiology.Clinical parkinsonism & related disorders · 2026Review
- Astrocytes in Pain Perception: A Systems Neuroscience Approach.Advances in neurobiology · 2024Review
- Visual light flicker stimulation: enhancing alertness in sleep-deprived rats.Frontiers in neuroscience · 2024Article
- Thalamic control of sensory processing and spindles in a biophysical somatosensory thalamoreticular circuit model of wakefulness and sleep.Cell reports · 2023Article
- Role of the locus coeruleus and basal forebrain in arousal and attention.Brain research bulletin · 2022Review
- State-dependent effects of neural stimulation on brain function and cognition.Nature reviews. Neuroscience · 2022Review
- Thalamocortical Spectral Transmission Relies on Balanced Input Strengths.Brain topography · 2022Article
- State-dependent modulation of thalamocortical oscillations by gamma light flicker with different frequencies, intensities, and duty cycles.Frontiers in neuroinformatics · 2022Article
- Impact of GABAThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Transcranial alternating current stimulation entrains alpha oscillations by preferential phase synchronization of fast-spiking cortical neurons to stimulation waveform.Nature communications · 2021Article
- Multiscale neural modeling of resting-state fMRI reveals executive-limbic malfunction as a core mechanism in major depressive disorder.NeuroImage. Clinical · 2021Article
- Relations between large-scale brain connectivity and effects of regional stimulation depend on collective dynamical state.PLoS computational biology · 2020Article
- An Attempt at a Unified Theory of the Neocortical Microcircuit in Sensory Cortex.Frontiers in neural circuits · 2020Article
- Revealing the Computational Meaning of Neocortical Interarea Signals.Frontiers in computational neuroscience · 2020Article
- Spectral organization of focal seizures within the thalamotemporal network.Annals of clinical and translational neurology · 2019Article
- Rhythmic modulation of thalamic oscillations depends on intrinsic cellular dynamics.Journal of neural engineering · 2019Article
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Abstract
The thalamus plays a critical role in the genesis of thalamocortical oscillations, yet the underlying mechanisms remain elusive. To understand whether the isolated thalamus can generate multiple distinct oscillations, we developed a biophysical thalamic model to test the hypothesis that generation of and transition between distinct thalamic oscillations can be explained as a function of neuromodulation by acetylcholine (ACh) and norepinephrine (NE) and afferent synaptic excitation. Indeed, the model exhibited four distinct thalamic rhythms (delta, sleep spindle, alpha and gamma oscillations) that span the physiological states corresponding to different arousal levels from deep sleep to focused attention. Our simulation results indicate that generation of these distinct thalamic oscillations is a result of both intrinsic oscillatory cellular properties and specific network connectivity patterns. We then systematically varied the ACh/NE and input levels to generate a complete map of the different oscillatory states and their transitions. Lastly, we applied periodic stimulation to the thalamic network and found that entrainment of thalamic oscillations is highly state-dependent. Our results support the hypothesis that ACh/NE modulation and afferent excitation define thalamic oscillatory states and their response to brain stimulation. Our model proposes a broader and more central role of the thalamus in the genesis of multiple distinct thalamo-cortical rhythms than previously assumed.
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