Evidence map›Paper›PMID 29073112›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2017

Dynein/dynactin is necessary for anterograde transport of

Amy L Herbert, Meng-Meng Fu, Catherine M Drerup, Ryan S Gray, Breanne L Harty, Sarah D Ackerman, Thomas O'Reilly-Pol, Stephen L Johnson, Alex V Nechiporuk, Ben A Barres and 1 more

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 64 citations in OpenAlex.

  1. Article
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  15. A Bioinspired Self-Healing Conductive Hydrogel Promoting Peripheral Nerve Regeneration.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Amy L HerbertDepartment of Developmental Biology, Washington University School of Medicine, St. Louis, MO 63110.
Meng-Meng FuDepartment of Neurobiology, Stanford University School of Medicine, Stanford, CA 94305; mengmengfu@gmail.com barres@stanford.edu monk@ohsu.edu.
Catherine M DrerupDepartment of Cell, Developmental & Cancer Biology, Oregon Health and Science University, Portland, OR 97239.
Ryan S GrayDepartment of Developmental Biology, Washington University School of Medicine, St. Louis, MO 63110.
Breanne L HartyDepartment of Developmental Biology, Washington University School of Medicine, St. Louis, MO 63110.
Sarah D AckermanDepartment of Developmental Biology, Washington University School of Medicine, St. Louis, MO 63110.
Thomas O'Reilly-PolDepartment of Genetics, Washington University School of Medicine, St. Louis, MO 63110.
Stephen L JohnsonDepartment of Genetics, Washington University School of Medicine, St. Louis, MO 63110.
Alex V NechiporukDepartment of Cell, Developmental & Cancer Biology, Oregon Health and Science University, Portland, OR 97239.
Ben A BarresDepartment of Neurobiology, Stanford University School of Medicine, Stanford, CA 94305; mengmengfu@gmail.com barres@stanford.edu monk@ohsu.edu.
Kelly R MonkDepartment of Developmental Biology, Washington University School of Medicine, St. Louis, MO 63110; mengmengfu@gmail.com barres@stanford.edu monk@ohsu.edu.
Washington University in St. Louis · USOregon Health & Science University · USStanford University · US

Funding

REGULATION OF ADULT STEM CELLS IN ZEBRAFISHR01GM056988 · NIGMS · WASHINGTON UNIVERSITY · PI JOHNSON, STEPHEN L · 1998 to 2016
$6.0M
TRAINING IN NEONATAL BIOLOGYT32HD007249 · NICHD · STANFORD UNIVERSITY · PI STEVENSON, DAVID K · 1985 to 2013
$4.4M
Regulation of retrograde cargo transport in axonsZIAHD008964 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI DRERUP, CATHERINE M · 2017 to 2020
$2.8M
Chemical and genetic screens for modulators of nervous system development and myelinationR01HD080601 · NICHD · WASHINGTON UNIVERSITY · PI MONK, KELLY R · 2014 to 2018
$1.6M
Genetic analyses of axon transport and microtubule dynamics in ZebrafishR01HD072844 · NICHD · OREGON HEALTH & SCIENCE UNIVERSITY · PI NECHIPORUK, ALEX · 2012 to 2016
$1.6M
Gpr56 is a regulator of glial cell development and myelinationF31NS087801 · NINDS · WASHINGTON UNIVERSITY · PI ACKERMAN, SARAH D · 2014 to 2016
$68k
Control of myelinating glial cell development by actr10F31NS096814 · NINDS · WASHINGTON UNIVERSITY · PI HERBERT, AMY · 2016 to 2017
$61k
MOLECULAR CONTROL OF MYELINATING GLIAL CELL DEVELOPMENT BY FBXW7F31NS094004 · NINDS · WASHINGTON UNIVERSITY · PI HARTY, BREANNE LEIGH · 2015 to 2016
$52k
Mechanisms and Functions of MBP mRNA Transport in OligodendrocytesF32NS090721 · NINDS · STANFORD UNIVERSITY · PI FU, MENG-MENG · 2014 to 2014
$21k
NICHD NIH HHS R01 HD072844NICHD NIH HHS R01 HD080601NICHD NIH HHS T32 HD007249NIGMS NIH HHS R01 GM056988NINDS NIH HHS F31 NS087801NINDS NIH HHS F31 NS094004NINDS NIH HHS F31 NS096814NINDS NIH HHS F32 NS090721
6 · The paper itself

Abstract

Oligodendrocytes in the central nervous system produce myelin, a lipid-rich, multilamellar sheath that surrounds axons and promotes the rapid propagation of action potentials. A critical component of myelin is myelin basic protein (MBP), expression of which requires anterograde mRNA transport followed by local translation at the developing myelin sheath. Although the anterograde motor kinesin KIF1B is involved in

Indexed as

AnimalsAnimals, Genetically ModifiedAxonsBiological TransportCell ProliferationCells, CulturedDynactin ComplexDyneinsLarvaMicrofilament ProteinsMyelin Basic ProteinOligodendrogliaRats, Sprague-DawleyRNA, MessengerZebrafishZebrafish ProteinsDynactin ComplexDyneinsMicrofilament ProteinsMyelin Basic ProteinRNA, MessengerZebrafish ProteinsdynactindyneinmRNA transportmyelinationoligodendrocytes

Identifiers

PMID29073112
PMCPMC5664533
OpenAlexW2761400279

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.