Evidence map›Paper›PMID 29073107›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2017

Spatial organization of a model 15-member human gut microbiota established in gnotobiotic mice.

Jessica L Mark Welch, Yuko Hasegawa, Nathan P McNulty, Jeffrey I Gordon, Gary G Borisy

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 154 papers.

0numbers the graph read from it
0cells of the map it votes in
154citing papers in PubMed
11.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

154 citing papers in PubMed, 248 citations in OpenAlex.

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  7. Geometric ordering in bacterial communities.Proceedings of the National Academy of Sciences of the United States of America · 2026
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94 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Jessica L Mark WelchThe Josephine Bay Paul Center for Comparative Molecular Biology and Evolution, Marine Biological Laboratory, Woods Hole, MA 02543; jmarkwelch@mbl.edu gborisy@forsyth.org.
Yuko HasegawaThe Josephine Bay Paul Center for Comparative Molecular Biology and Evolution, Marine Biological Laboratory, Woods Hole, MA 02543.
Nathan P McNultyCenter for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO 63110.
Jeffrey I GordonCenter for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO 63110.
Gary G BorisyDepartment of Microbiology, The Forsyth Institute, Cambridge, MA 02142 jmarkwelch@mbl.edu gborisy@forsyth.org.
Marine Biological Laboratory · USWashington University in St. Louis · US

Funding

Trace the flow of genes in the gut microbiome of obese and lean twin pairsP01DK078669 · NIDDK · WASHINGTON UNIVERSITY · PI GORDON, JEFFREY I · 2007 to 2018
$16.0M
Spatial Organization of the Oral MicrobiomeR01DE022586 · NIDCR · MARINE BIOLOGICAL LABORATORY · PI Jessica Leigh Mark Welch · 2013 to 2026
$8.7M
REGULATION OF GENE EXPRESSION - SMALL INTESTINER01DK030292 · NIDDK · WASHINGTON UNIVERSITY · PI JEFFREY I GORDON, ANDREI L OSTERMAN · 1986 to 2026
$6.5M
GUT MICROBIOTA AND OBESITY: STUDIES IN GNOTOBIOTIC MICER01DK070977 · NIDDK · WASHINGTON UNIVERSITY · PI GORDON, JEFFREY I, HETTICH, ROBERT L. · 2005 to 2020
$6.3M
REGULATION OF GENE EXPRESSION IN THE SMALL INTESTINER37DK030292 · NIDDK · WASHINGTON UNIVERSITY · PI GORDON, JEFFREY I · 1993 to 2015
$4.0M
NIDCR NIH HHS R01 DE022586NIDDK NIH HHS P01 DK078669NIDDK NIH HHS R01 DK030292NIDDK NIH HHS R01 DK070977NIDDK NIH HHS R37 DK030292
6 · The paper itself

Abstract

Knowledge of the spatial organization of the gut microbiota is important for understanding the physical and molecular interactions among its members. These interactions are thought to influence microbial succession, community stability, syntrophic relationships, and resiliency in the face of perturbations. The complexity and dynamism of the gut microbiota pose considerable challenges for quantitative analysis of its spatial organization. Here, we illustrate an approach for addressing this challenge, using (

Indexed as

Gastrointestinal MicrobiomeAnimalsColonHumansIn Situ Hybridization, FluorescenceIntestinal MucosaMaleMice, Inbred C57BLbacterial–bacterial interactionscommunity biogeographygut microbial ecologymicrobiome functionmultiplex fluorescence imaging

Identifiers

PMID29073107
PMCPMC5664539
OpenAlexW2763048132

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.