Evidence map›Paper›PMID 29073106›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2017

Cardiovascular homeostasis dependence on MICU2, a regulatory subunit of the mitochondrial calcium uniporter.

Alexander G Bick, Hiroko Wakimoto, Kimberli J Kamer, Yasemin Sancak, Olga Goldberger, Anna Axelsson, Daniel M DeLaughter, Joshua M Gorham, Vamsi K Mootha, J G Seidman and 1 more

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed
11.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 69 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Role of mitochondrial CaMolecular medicine reports · 2025
    Review
  5. Review
  6. Article
  7. Article
  8. Review
  9. Calcium signaling in mitochondrial intermembrane space.Biochemical Society transactions · 2024
    Review
  10. MICU1 and MICU2 control mitochondrial calcium signaling in the mammalian heart.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  11. Article
  12. Review
  13. CaBiomedical reports · 2024
    Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Alexander G BickDepartment of Genetics, Harvard Medical School, Boston, MA 02115.ORCID 0000-0001-5824-9595
Hiroko WakimotoDepartment of Genetics, Harvard Medical School, Boston, MA 02115.
Kimberli J KamerDepartment of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114.ORCID 0000-0001-8728-7793
Yasemin SancakDepartment of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114.
Olga GoldbergerDepartment of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114.
Anna AxelssonDepartment of Genetics, Harvard Medical School, Boston, MA 02115.
Daniel M DeLaughterDepartment of Genetics, Harvard Medical School, Boston, MA 02115.
Joshua M GorhamDepartment of Genetics, Harvard Medical School, Boston, MA 02115.
Vamsi K MoothaDepartment of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114.
J G SeidmanDepartment of Genetics, Harvard Medical School, Boston, MA 02115.
Christine E SeidmanDepartment of Genetics, Harvard Medical School, Boston, MA 02115; cseidman@genetics.med.harvard.edu.ORCID 0000-0001-6380-1209
Harvard University · USBrigham and Women's Hospital · USHoward Hughes Medical Institute · US

Funding

Medical Scientist Training ProgramT32GM007753 · NIGMS · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI WALENSKY, LOREN DAVID · 1985 to 2021
$50.0M
Howard Hughes Medical InstituteNIGMS NIH HHS T32 GM007753
6 · The paper itself

Abstract

Comparative analyses of transcriptional profiles from humans and mice with cardiovascular pathologies revealed consistently elevated expression of

Indexed as

Angiotensin AmideAngiotensin IIAnimalsAorta, AbdominalCalciumCalcium-Binding ProteinsCalcium ChannelsCardiomyopathy, Hypertrophic, FamilialElectrocardiographyGene Expression RegulationHomeostasisHumansMice, Inbred C57BLMice, Mutant StrainsMitochondria, LiverMyocytes, CardiacAngiotensin AmideAngiotensin IICalciumCalcium-Binding ProteinsCalcium ChannelsMICU2 protein, humanMicu2 protein, mouseaortic aneurysmscalciumdiastolic dysfunctionhypertensionmitochondrial calcium uniporter

Identifiers

PMID29073106
PMCPMC5664535
OpenAlexW2761476578

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.