Evidence map›Paper›PMID 29073098›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2017

Modulation of apoptotic response by LAR family phosphatases-cIAP1 signaling during urinary tract morphogenesis.

Katherine Stewart, You Chi Tang, Maxwell E R Shafer, Adda-Lee Graham-Paquin, Maxime Bouchard

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Evaluation of PGP 9.5, NGFR, TGFβ1, FGFR1, MMP-2, AT2R2, SHH, and TUNEL in Primary Obstructive Megaureter Tissue.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2022
    Article
  2. Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Katherine StewartDepartment of Biochemistry, McGill University, Montreal, QC, Canada H3G 1Y6.
You Chi TangDepartment of Biochemistry, McGill University, Montreal, QC, Canada H3G 1Y6.
Maxwell E R ShaferDepartment of Biochemistry, McGill University, Montreal, QC, Canada H3G 1Y6.
Adda-Lee Graham-PaquinDepartment of Biochemistry, McGill University, Montreal, QC, Canada H3G 1Y6.
Maxime BouchardDepartment of Biochemistry, McGill University, Montreal, QC, Canada H3G 1Y6; maxime.bouchard@mcgill.ca.ORCID 0000-0002-7619-9680
McGill University Health Centre · CA

Funding

CIHR MOP-84343
6 · The paper itself

Abstract

The elimination of unwanted cells by apoptosis is necessary for tissue morphogenesis. However, the cellular control of morphogenetic apoptosis is poorly understood, notably the modulation of cell sensitivity to apoptotic stimuli. Ureter maturation, the process by which the ureter is displaced to the bladder wall, represents an exquisite example of morphogenetic apoptosis, requiring the receptor protein tyrosine phosphatases (RPTPs): LAR and RPTPσ. Here we show that LAR-RPTPs act through cellular inhibitor of apoptosis protein 1 (cIAP1) to modulate caspase 3,7-mediated ureter maturation. Pharmacologic or genetic inactivation of cIAP1 reverts the apoptotic deficit of LAR-RPTP-deficient embryos. Moreover,

Indexed as

AnimalsApoptosisCaspase 3Cells, CulturedEmbryo, MammalianFibroblastsGene Expression Regulation, DevelopmentalInhibitor of Apoptosis ProteinsMiceMice, KnockoutReceptor-Like Protein Tyrosine Phosphatases, Class 2Signal TransductionUbiquitin-Protein LigasesUreterCaspase 3Inhibitor of Apoptosis ProteinsReceptor-Like Protein Tyrosine Phosphatases, Class 2Ubiquitin-Protein LigasesapoptosiscIAP1LAR receptor protein tyrosine phosphatasesurinary tract morphogenesisvesicoureteral reflux

Identifiers

PMID29073098
PMCPMC5664512
OpenAlexW2763172278

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.