ArticleProceedings of the National Academy of Sciences of the United States of America2017
Nonequilibrium fluctuations of lipid membranes by the rotating motor protein F
Article in Proceedings of the National Academy of Sciences of the United States of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 55 citations in OpenAlex.
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- Force Generation by Enhanced Diffusion in Enzyme-Loaded Vesicles.Nano letters · 2025Article
- Functional reconstitution of plant plasma membrane HScientific reports · 2025Article
- Active membrane deformations of a minimal synthetic cell.Nature physics · 2025Article
- Non-equilibrium self-assembly for living matter-like properties.Nature reviews. Chemistry · 2024Review
- Kinetically Controlled and Nonequilibrium Assembly of Block Copolymers in Solution.Journal of the American Chemical Society · 2024Review
- Red blood cell flickering activity locally controlled by holographic optical tweezers.iScience · 2024Article
- Electron videography of a lipid-protein tango.Science advances · 2024Article
- Formation of Cell-Sized Liposomes Incorporating a β-Barrel-Structured Porin through Rehydration of a Phospholipid-Membrane Protein Dried Film.ACS omega · 2024Article
- Synthetic Cells Revisited: Artificial Cells Construction Using Polymeric Building Blocks.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Review
- Light-Driven Membrane Assembly, Shape-Shifting, and Tissue Formation in Chemically Responsive Synthetic Cells.Journal of the American Chemical Society · 2023Article
- Rotation of the c-Ring Promotes the Curvature Sorting of Monomeric ATP Synthases.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- Activity modulation of theiScience · 2023Article
- Function Investigations and Applications of Membrane Proteins on Artificial Lipid Membranes.International journal of molecular sciences · 2023Review
- Experimental platform for the functional investigation of membrane proteins in giant unilamellar vesicles.Soft matter · 2022Article
- Molecular Shape Solution for Mesoscopic Remodeling of Cellular Membranes.Annual review of biophysics · 2022Review
- Membrane rigidity regulates E. coli proliferation rates.Scientific reports · 2022Article
- Mitochondrial membrane models built from native lipid extracts: Interfacial and transport properties.Frontiers in molecular biosciences · 2022Article
- En route to dynamic life processes by SNARE-mediated fusion of polymer and hybrid membranes.Nature communications · 2021Article
- Mitochondrial Cristae Architecture and Functions: Lessons from Minimal Model Systems.Membranes · 2021Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
ATP synthase is a rotating membrane protein that synthesizes ATP through proton-pumping activity across the membrane. To unveil the mechanical impact of this molecular active pump on the bending properties of its lipid environment, we have functionally reconstituted the ATP synthase in giant unilamellar vesicles and tracked the membrane fluctuations by means of flickering spectroscopy. We find that ATP synthase rotates at a frequency of about 20 Hz, promoting large nonequilibrium deformations at discrete hot spots in lipid vesicles and thus inducing an overall membrane softening. The enhanced nonequilibrium fluctuations are compatible with an accumulation of active proteins at highly curved membrane sites through a curvature-protein coupling mechanism that supports the emergence of collective effects of rotating ATP synthases in lipid membranes.
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