ArticleProceedings of the National Academy of Sciences of the United States of America2017
Allocating dissipation across a molecular machine cycle to maximize flux.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Multistate Kinetic Model of the Sodium-Potassium ATPase.The journal of physical chemistry. B · 2025Article
- Exploring the Evolution-Coupling Hypothesis: Do Enzymes' Performance Gains Correlate with Increased Dissipation?Entropy (Basel, Switzerland) · 2025Article
- Specificity and tunability of efflux pumps: A new role for the proton gradient?PLoS computational biology · 2025Article
- Theoretical efficiency limits and speed-efficiency trade-off in myosin motors.PLoS computational biology · 2023Article
- Thermodynamic selection: mechanisms and scenarios.New journal of physics · 2022Article
- Effect of varying load in moving period of a step on dynamics of molecular motors.The European physical journal. E, Soft matter · 2022Article
- Evolution of mechanical cooperativity among myosin II motors.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Reversible catalysis.Nature reviews. Chemistry · 2021Review
- Optimizing enzymatic catalysts for rapid turnover of substrates with low enzyme sequestration.Biological cybernetics · 2020Article
- Energy dissipation bounds for autonomous thermodynamic cycles.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Allostery and Kinetic Proofreading.The journal of physical chemistry. B · 2019Article
- Opposing Pressures of Speed and Efficiency Guide the Evolution of Molecular Machines.Molecular biology and evolution · 2019Article
- Inferring broken detailed balance in the absence of observable currents.Nature communications · 2019Article
- Quantifying dissipation using fluctuating currents.Nature communications · 2019Article
- Mechanisms for achieving high speed and efficiency in biomolecular machines.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
Corrections and comments
- Erratum issued
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Biomolecular machines consume free energy to break symmetry and make directed progress. Nonequilibrium ATP concentrations are the typical free energy source, with one cycle of a molecular machine consuming a certain number of ATP, providing a fixed free energy budget. Since evolution is expected to favor rapid-turnover machines that operate efficiently, we investigate how this free energy budget can be allocated to maximize flux. Unconstrained optimization eliminates intermediate metastable states, indicating that flux is enhanced in molecular machines with fewer states. When maintaining a set number of states, we show that-in contrast to previous findings-the flux-maximizing allocation of dissipation is not even. This result is consistent with the coexistence of both "irreversible" and reversible transitions in molecular machine models that successfully describe experimental data, which suggests that, in evolved machines, different transitions differ significantly in their dissipation.
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