ArticleVirulence2018
Streptococcus gallolyticus subsp. gallolyticus endocarditis isolate interferes with coagulation and activates the contact system.
Article in Virulence, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 33 citations in OpenAlex.
- Gut-Heart Axis and Infective Endocarditis: How Microbiota Dysbiosis Shapes Cardiovascular Risk and Infection Susceptibility.Journal of clinical medicine · 2026Review
- Bacterial factors required for biofilm formation inFrontiers in cellular and infection microbiology · 2026Article
- The evolving story ofFrontiers in microbiology · 2026Review
- Bacterial infection and activation of the contact pathway of coagulation.Blood vessels, thrombosis & hemostasis · 2025Review
- Colorectal cancer-associatedJournal of bacteriology · 2025Article
- Factor XII-driven coagulation traps bacterial infections.The Journal of experimental medicine · 2025Article
- Article
- The Potential Role of Boron in the Modulation of Gut Microbiota Composition: An In Vivo Pilot Study.Pharmaceuticals (Basel, Switzerland) · 2024Article
- First Report on theInternational journal of molecular sciences · 2022Article
- A Cyclic di-GMP Network Is Present in Gram-PositiveACS infectious diseases · 2020Article
- Central retinal artery occlusion fromBMJ case reports · 2020Article
- Extensive bacteriocin gene shuffling in the Streptococcus bovis/Streptococcus equinus complex reveals gallocin D with activity against vancomycin resistant enterococci.Scientific reports · 2020Article
- The contact system proteases play disparate roles in streptococcal sepsis.Haematologica · 2020Article
- Streptococcus gallolyticus abrogates anti-carcinogenic properties of tannic acid on low-passage colorectal carcinomas.Scientific reports · 2020Article
- Prothrombotic and Proinflammatory Activities of the β-Hemolytic Group B Streptococcal Pigment.Journal of innate immunity · 2020Article
- The Versatility of Opportunistic Infections Caused byFrontiers in microbiology · 2020Article
- Is Echocardiography Mandatory for AllInfection and drug resistance · 2020Article
- Roles of Factor XII in Innate Immunity.Frontiers in immunology · 2019Review
- Article
- The Road to Infection: Host-Microbe Interactions Defining the Pathogenicity ofFrontiers in microbiology · 2018Review
Corrections and comments
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Authors and funding
10 authors at 6 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Streptococcus gallolyticus subsp. gallolyticus, formerly classified as S. bovis biotype I, is an increasing cause of bacteremia and infective endocarditis in the elderly. The physiopathology of infective endocarditis is poorly understood and involves immune and coagulation systems. In this study, we found that S. gallolyticus subsp. gallolyticus activates the human contact system, which in turn has two consequences: cleavage of high-molecular-weight kininogen (HK) resulting in release of the potent pro-inflammatory peptide bradykinin, and initiation of the intrinsic pathway of coagulation. S. gallolyticus subsp. gallolyticus was found to bind and activate factors of the human contact system at its surface, leading to a significant prolongation of the intrinsic coagulation time and to the release of bradykinin. High-affinity binding of factor XII to the bacterial Pil1 collagen binding protein was demonstrated with a K
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.