ArticleGenetic epidemiology2018
On the testing of Hardy-Weinberg proportions and equality of allele frequencies in males and females at biallelic genetic markers.
Article in Genetic epidemiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed.
- Population-Based Genetic Assessment of Thrombophilia Polymorphisms: Allelic Frequencies and Population Linkage Dynamics.Medicina (Kaunas, Lithuania) · 2025Observational
- Genotype-Phenotype Correlation of TNF-α (-238, rs361525) and Cystatin C for Early Detection of Sepsis-Associated AKI and Its Severity in Critically Ill Neonates.International journal of molecular sciences · 2025Article
- eXclusionarY: 10 years later, where are the sex chromosomes in GWASs?American journal of human genetics · 2023Review
- Major sex differences in allele frequencies for X chromosomal variants in both the 1000 Genomes Project and gnomAD.PLoS genetics · 2022Article
- A framework for research into continental ancestry groups of the UK Biobank.Human genomics · 2022Article
- Molecular Epidemiology of NaFrontiers in genetics · 2022Article
- Molecular epidemiologic study of citrin deficiency by screening for four reported pathogenic SLC25A13 variants in the Shaanxi and Guangdong provinces, China.Translational pediatrics · 2021Article
- The geographic mosaic of arms race coevolution is closely matched to prey population structure.Evolution letters · 2020Article
- Article
- Bayesian model selection for the study of Hardy-Weinberg proportions and homogeneity of gender allele frequencies.Heredity · 2019Article
- Multi-allelic exact tests for Hardy-Weinberg equilibrium that account for gender.Molecular ecology resources · 2018Article
- On the testing of Hardy-Weinberg proportions and equality of allele frequencies in males and females at biallelic genetic markers.Genetic epidemiology · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Standard statistical tests for equality of allele frequencies in males and females and tests for Hardy-Weinberg equilibrium are tightly linked by their assumptions. Tests for equality of allele frequencies assume Hardy-Weinberg equilibrium, whereas the usual chi-square or exact test for Hardy-Weinberg equilibrium assume equality of allele frequencies in the sexes. In this paper, we propose ways to break this interdependence in assumptions of the two tests by proposing an omnibus exact test that can test both hypotheses jointly, as well as a likelihood ratio approach that permits these phenomena to be tested both jointly and separately. The tests are illustrated with data from the 1000 Genomes project.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.