ArticleJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology2019
Added prognostic value of left ventricular shape by gated SPECT imaging in patients with suspected coronary artery disease and normal myocardial perfusion.
Article in Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Left ventricular sphericity indexes by gated single photon emission computed tomography myocardial perfusion imaging: potential opportunities and challenges for cardiac remodeling and clinical prognosis-a narrative review.Quantitative imaging in medicine and surgery · 2025Review
- Assessment of Left Ventricular Shape Index and Eccentricity Index as Promising Parameters for Detection of Left Ventricular Remodeling in Cardiovascular Events.Current cardiology reviews · 2025Review
- Prognostic Value of Resting Left Ventricular Sphericity Indexes in Coronary Artery Disease With Preserved Ejection Fraction.Journal of the American Heart Association · 2024Article
- Association of epicardial fat volume with subclinical myocardial damage in patients with type 2 diabetes mellitus.Quantitative imaging in medicine and surgery · 2024Article
- Spherization indices measured by resting SPECT improve risk stratification in patients with ischemia with non-obstructive coronary artery disease (INOCA).EJNMMI research · 2024Article
- Machine learning to predict hemodynamically significant CAD based on traditional risk factors, coronary artery calcium and epicardial fat volume.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023Article
- Cardiac remodelling in association with left ventricular dyssynchrony and systolic dysfunction in patients with coronary artery disease.Clinical physiology and functional imaging · 2022Article
- Radionuclide imaging of jeopardized myocardium: From the beginning of the race to the finish line.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021Article
- Myocardial perfusion imaging for diabetes: Key points from the evidence and clinical questions to be answered.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2020Review
- Long-term prognostic value of low-dose normal stress-only myocardial perfusion imaging by wide beam reconstruction: A competing risk analysis.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2020Article
- The machine learning approach: Artificial intelligence is coming to support critical clinical thinking.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2020Article
- Is left ventricular systolic index the new kid in the block?Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2019Article
- Behind Traditional Semi-quantitative Scores of Myocardial Perfusion Imaging: An Eye on Niche Parameters.European cardiology · 2019Review
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12 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundLeft ventricular (LV) remodeling is associated with adverse cardiovascular events. We evaluated the added prognostic value of LV shape index (SI) assessed by gated single-photon emission tomography (SPECT) in patients without known coronary artery disease (CAD). METHODS AND
resultsWe studied 674 patients with normal myocardial perfusion and normal LV ejection fraction (EF) on stress gated SPECT imaging. An automated software program was used to calculate end-diastolic and end-systolic LVSI. An LVSI ≤ 0.54 at end-systole was considered normal. Follow-up was 96% complete with a median follow-up of 37 months. During follow-up, 25 events occurred (3.8% cumulative event rate). Event-free survival was lower in patients with abnormal end-systolic LVSI (P < .001). Age (P = .021), diabetes (P = .048), and end-systolic LVSI (P < .001) were independent predictors of events. LVSI added prognostic information increasing the global chi-square of the model including age and diabetes from 15.15 to 25.97 (P < .001). The effect of diabetes on hazard ratio increased with increasing values of end-systolic LVSI. The probability of events at 48 months predicted by Weibull analysis progressively increased with increasing values of end-systolic LVSI and was higher in patients with diabetes as compared to those without. Decision curve analyses indicate that the model including end-systolic LVSI resulted in an increased net benefit between 5% and 30% threshold probability, indicating superior estimation of outcomes at low threshold probability levels.
conclusionsThe evaluation of LVSI may identify patients with early-stage LV remodeling and at higher risk of adverse cardiac events, even in the presence of normal myocardial perfusion.
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