ReviewCurrent obesity reports2017
Obesity, Appetite, and the Prefrontal Cortex.
Review in Current obesity reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
67 citing papers in PubMed, 4 syntheses or guidelines pooled it, 136 citations in OpenAlex.
- Network-Level Convergence of Adiposity-Related Gray Matter Alterations: A Coordinate-Based Connectome Mapping Meta-Analysis With Imaging Transcriptomics.Human brain mapping · 2026Pooled it
- Impact of neuroregulatory interventions upon weight in patients with mental illness: a meta-analysis of randomised controlled trials.BMC psychiatry · 2025Pooled it
- Altered functional connectivity of brain regions based on a meta-analysis in patients with T2DM: A resting-state fMRI study.Brain and behavior · 2020Pooled it
- The Executive Functions in Overweight and Obesity: A Systematic Review of Neuropsychological Cross-Sectional and Longitudinal Studies.Frontiers in psychology · 2019Pooled it
- Prefrontal cortex activation by binge-eating status in individuals with obesity while attempting to reappraise responses to food using functional near infrared spectroscopy.Eating and weight disorders : EWD · 2023Trial
- Sex differences in central insulin action: Effect of intranasal insulin on neural food cue reactivity in adults with normal weight and overweight.International journal of obesity (2005) · 2022Trial
- Reduction of impulsivity in patients receiving deep transcranial magnetic stimulation treatment for obesity.Endocrine · 2021Trial
- Neuromodulation of the prefrontal cortex facilitates diet-induced weight loss in midlife women: a randomized, proof-of-concept clinical trial.International journal of obesity (2005) · 2020Trial
- High frequency deep transcranial magnetic stimulation acutely increases β-endorphins in obese humans.Endocrine · 2019Trial
- Observational
- fNIRS estimates prefrontal cortex activation following glucose load in youths with obesity.Journal of endocrinological investigation · 2026Article
- Effects of a single dose of psilocybin on diet-induced weight loss in obese mice.Translational psychiatry · 2026Article
- Crosstalk between alcohol use disorder and obesity: two sides of the same coin?Molecular psychiatry · 2025Review
- Body Mass Index Impacts on Gray Matter Volume in Developmental Restrictive Anorexia Nervosa: A Voxel-Based Morphometry Study.Nutrients · 2025Article
- Reward responses to vicarious feeding depend on body mass index.Cognitive, affective & behavioral neuroscience · 2025Article
- Executive Function Response to Moderate-to-High-Intensity Rope Skipping in Overweight Adolescents Aged 12-14: A Preliminary Study.Journal of functional morphology and kinesiology · 2025Article
- Article
- Clinical study of wearable low-intensity pulsed ultrasound treatment in the improvement of executive function in obesity (the SLITE trial): protocol for a single -centre, double-blind, randomized controlled trial.Frontiers in human neuroscience · 2025Article
- A study on appetite of overweight/obese patients with type 2 diabetes mellitus based on multimodal magnetic resonance imaging.Frontiers in neuroimaging · 2025Article
- Human brain proteome-wide association study provides insights into the genetic components of protein abundance in obesity.International journal of obesity (2005) · 2024Article
7 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purpose of reviewObesity is a chronic illness and its prevalence is growing worldwide and numerous factors play a role in the regulation of food intake. The prefrontal cortex (PFC) is involved in high-order executive function, regulation of limbic reward regions, and the inhibition of impulsive behaviors. Understanding the role of the PFC in the control of appetite regulation may contribute to a greater understanding of the etiology of obesity and could improve weight loss outcomes. RECENT
findingsNeuroimaging studies have identified lower activation in the left dorsolateral PFC (DLPFC) in obese compared to lean individuals and others have focused on efforts to improve cognitive control in this area of the brain. The DLPFC is a critical brain area associated with appetitive control, food craving, and executive functioning, indicating a candidate target area for treatment. Further studies are needed to advance our understanding of the relationship between obesity, appetite, and the DLPFC and provide validation for the effectiveness of novel treatments in clinical populations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.