ArticleFish physiology and biochemistry2018
Effects of acute handling stress on short-term central expression of orexigenic/anorexigenic genes in zebrafish.
Article in Fish physiology and biochemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed.
- Microplastic Exposure Disrupts Energy Homeostasis and Welfare in Goldfish.Animals : an open access journal from MDPI · 2026Article
- Loss-of-function mutations in the melanocortin-2-receptor (mc2r) lead to skin hyperpigmentation in teleost fish.Scientific reports · 2026Article
- Density-Dependent Expression of Epitranscriptomic, Stress and Appetite Regulating Genes in Atlantic Salmon.Molecular ecology · 2026Article
- A functional framework for a comprehensive study of welfare in fishes.Proceedings. Biological sciences · 2025Review
- Steroid 21-hydroxylase deficiency dysregulates essential molecular pathways of metabolism and energy provision.Biology open · 2025Article
- Acute Stress Effects over Time on Gene Expression Patterns in the Male Zebrafish (Animals : an open access journal from MDPI · 2025Article
- Cross-regulatory interaction between the HPI axis and appetite regulation in Atlantic salmon (Frontiers in endocrinology · 2025Article
- Acute Stress Effects over Time on the Gene Expression and Neurotransmitter Patterns in the Carp (Animals : an open access journal from MDPI · 2024Article
- Multiple faces of stress in the zebrafish (Frontiers in physiology · 2024Article
- Article
- Effects of different acute stressors on the regulation of appetite genes in the carp (Royal Society open science · 2023Article
- Advances in Zebrafish as a Comprehensive Model of Mental Disorders.Depression and anxiety · 2023Review
- Role of the Melanocortin System in Gonadal Steroidogenesis of Zebrafish.Animals : an open access journal from MDPI · 2022Article
- Glucocorticoid receptor activation reduces food intake independent of hyperglycemia in zebrafish.Scientific reports · 2022Article
- Skin swabbing is a refined technique to collect DNA from model fish species.Scientific reports · 2020Article
- Acute and chronic stress prevents responses to pain in zebrafish: evidence for stress-induced analgesia.The Journal of experimental biology · 2020Article
- Neuropeptide Y deficiency induces anxiety-like behaviours in zebrafish (Danio rerio).Scientific reports · 2020Article
- Characterization of the prohormone complement in Amphiprion and related fish species integrating genome and transcriptome assemblies.PloS one · 2020Article
- Map and model-moving from observation to prediction in toxicogenomics.GigaScience · 2019Article
- Stress Effects on the Mechanisms Regulating Appetite in Teleost Fish.Frontiers in endocrinology · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Physiological mechanisms driving stress response in vertebrates are evolutionarily conserved. These mechanisms involve the activation of both the hypothalamic-sympathetic-chromaffin cell (HSC) and the hypothalamic-pituitary-adrenal (HPA) axes. In fish, the reduction of food intake levels is a common feature of the behavioral response to stress but the central mechanisms coordinating the energetic response are not well understood yet. In this work, we explore the effects of acute stress on key central systems regulating food intake in fish as well as on total body cortisol and glucose levels. We show that acute stress induced a rapid increase in total body cortisol with no changes in body glucose, at the same time promoting a prompt central response by activating neuronal pathways. All three orexigenic peptides examined, i.e., neuropeptide y (npy), agouti-related protein (agrp), and ghrelin, increased their central expression level suggesting that these neuronal systems are not involved in the short-term feeding inhibitory effects of acute stress. By contrast, the anorexigenic precursors tested, i.e., cart peptides and pomc, exhibited increased expression after acute stress, suggesting their involvement in the anorexigenic effects.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.