ArticleEJNMMI research2017
Lower serotonin transporter binding in patients with cervical dystonia is associated with psychiatric symptoms.
Article in EJNMMI research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
7 citing papers in PubMed, 20 citations in OpenAlex.
- Trial
- The use of sertraline to treat an adolescent of dystonia comorbid with major depressive disorder with psychotic features.Neuropsychopharmacology reports · 2024Article
- Development of a New Care Pathway for Depression and Anxiety in Adult-Onset Isolated Dystonia.Movement disorders clinical practice · 2023Article
- Longitudinal analysis of the relationship between motor and psychiatric symptoms in idiopathic dystonia.European journal of neurology · 2022Article
- Cognitive and Neuropsychiatric Impairment in Dystonia.Current neurology and neuroscience reports · 2022Review
- Review
- Non-Motor Manifestations in Idiopathic Dystonia with Focal Onset - A Pilot Study.Journal of medicine and lifeArticle
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCervical dystonia (CD) is often accompanied by depressive symptoms, anxiety, and jerks/tremor. The dopamine transporter (DAT) binding is related with both depressive symptoms and jerks/tremor in CD. Serotonergic and dopaminergic systems are closely related. As serotonin is involved in the pathophysiology of psychiatric symptoms and jerks, we expected an altered serotoninergic system in CD. We hypothesized that CD is associated with reduced serotonin transporter (SERT) binding, more specific that SERT binding is lower in CD patients with psychiatric symptoms and/or jerks/tremor compared to those without, and to controls. The balance between SERT and DAT binding can be altered in different CD phenotypes.
resultsIn 23 CD patients and 14 healthy controls, SERT binding in the diencephalon/midbrain was assessed using [
conclusionCD patients with psychiatric symptoms have lower SERT binding in the midbrain/diencephalon, while dystonia and jerks appear unrelated to SERT binding. The balance between extrastriatal SERT and striatal DAT binding is different in CD with and without jerks.
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