Evidence map›Paper›PMID 29071300›Full record

ArticleeNeuro

Dopamine D2 Receptors in the Paraventricular Thalamus Attenuate Cocaine Locomotor Sensitization.

Abigail M Clark, Felix Leroy, Kelly M Martyniuk, Wendy Feng, Erika McManus, Matthew R Bailey, Jonathan A Javitch, Peter D Balsam, Christoph Kellendonk

Open access · goldAbstract read
In one paragraph

Article in eNeuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
1.4field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 48 citations in OpenAlex.

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  18. Drug addiction: from bench to bedside.Translational psychiatry · 2021
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Abigail M ClarkGraduate Program in Neurobiology and Behavior, College of Physicians and Surgeons, Columbia University, New York, NY 10032.ORCID 0000-0001-8908-9790
Felix LeroyDepartment of Neuroscience, College of Physicians and Surgeons, Columbia University, New York, NY 10032.ORCID 0000-0003-1715-3233
Kelly M MartyniukGraduate Program in Neurobiology and Behavior, College of Physicians and Surgeons, Columbia University, New York, NY 10032.ORCID 0000-0003-4190-4121
Wendy FengDepartment of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, NY 10032.ORCID 0000-0002-9734-8809
Erika McManusDepartment of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, NY 10032.
Matthew R BaileyDepartment of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, NY 10032.ORCID 0000-0002-9570-7505
Jonathan A JavitchDepartment of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, NY 10032.ORCID 0000-0001-7395-2967
Peter D BalsamDepartment of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, NY 10032.ORCID 0000-0001-7581-5499
Christoph KellendonkDepartment of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, NY 10032.ORCID 0000-0003-3302-2188
Columbia University · USNew York Psychoanalytic Society and Institute · US

Funding

Timing & Associative LearningR01MH068073 · NIMH · BARNARD COLLEGE · PI BALSAM, PETER D. · 2003 to 2024
$8.0M
Medium Spiny Neuron Excitability and MotivationR01MH093672 · NIMH · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI KELLENDONK, CHRISTOPH · 2011 to 2020
$5.0M
The role of thalamic dopamine D2 receptors in cocaine intakeR21DA044329 · NIDA · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI KELLENDONK, CHRISTOPH · 2017 to 2018
$413k
Dissection of mediodorsal thalamic circuitry underlying flexible behaviorF31MH106278 · NIMH · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI CLARK, ABIGAIL MARIE · 2014 to 2017
$181k
NIDA NIH HHS R21 DA044329NIMH NIH HHS F31 MH106278NIMH NIH HHS R01 MH068073NIMH NIH HHS R01 MH093672
6 · The paper itself

Abstract

Alterations in thalamic dopamine (DA) or DA D2 receptors (D2Rs) have been measured in drug addiction and schizophrenia, but the relevance of thalamic D2Rs for behavior is largely unknown. Using

Indexed as

AnimalsCocaineDopamine AgonistsDopamine AntagonistsDopamine Uptake InhibitorsDose-Response Relationship, DrugFearFemaleLocomotionMaleMaze LearningMembrane PotentialsMiceMice, Inbred C57BLMice, TransgenicMidline Thalamic NucleiCocaineDopamine AgonistsDopamine AntagonistsDopamine Uptake InhibitorsQuinpiroleReceptors, Dopamine D2Sulpirideanatomical tracingcocaine sensitizationdopamine D2 receptorsfear conditioningmidline thalamusparaventricular thalamus

Identifiers

PMID29071300
PMCPMC5654238
OpenAlexW2762194892

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.