ReviewNeuroImage. Clinical2018
How changes in brain activity and connectivity are associated with motor performance in people with MS.
Review in NeuroImage. Clinical, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- Neural correlates of dual-task walking in people with central neurological disorders: a systematic review.Journal of neurology · 2022Pooled it
- Transcutaneous electrical nerve stimulation enhances locomotor adaptation savings in people with multiple sclerosis.Brain communications · 2025Trial
- Resting-state functional connectivity correlates of gait and turning performance in multiple sclerosis: a multivariate pattern analysis.Scientific reports · 2025Article
- Rhythmic auditory cues improve gait asymmetry during unobstructed walking in people with Parkinson's disease but have no effect on obstacle avoidance - AsymmGait-Parkinson study.Frontiers in aging neuroscience · 2025Article
- Cross-sectional and longitudinal evaluation of white matter microstructure damage and cognitive correlations by automated fibre quantification in relapsing-remitting multiple sclerosis patients.Brain imaging and behavior · 2024Article
- Sex-related differences in upper limb motor function in healthy subjects and multiple sclerosis patients: a multiparametric MRI study.Journal of neurology · 2023Article
- Split-Belt Treadmill Adaptation Improves Spatial and Temporal Gait Symmetry in People with Multiple Sclerosis.Sensors (Basel, Switzerland) · 2023Article
- Diffusion tensor imaging metrics associated with future disability in multiple sclerosis.Scientific reports · 2023Article
- Assessment of Motor Evoked Potentials in Multiple Sclerosis.Sensors (Basel, Switzerland) · 2023Review
- (A)symmetry during gait initiation in people with Parkinson's disease: A motor and cortical activity exploratory study.Frontiers in aging neuroscience · 2023Article
- Characterization of sperm motility and testosterone secretion in theAnimal reproduction · 2023Article
- The association between cognition and motor performance is beyond structural damage in relapsing-remitting multiple sclerosis.Journal of neurology · 2022Article
- Combining advanced MRI and EEG techniques better explains long-term motor outcome after very preterm birth.Pediatric research · 2022Article
- Brain activation patterns of female multiple sclerosis patients with voiding dysfunction.Neurourology and urodynamics · 2020Article
- Neurodiagnostics in Sports: Investigating the Athlete's Brain to Augment Performance and Sport-Specific Skills.Frontiers in human neuroscience · 2020Article
- Morphological MRI phenotypes of multiple sclerosis differ in resting-state brain function.Scientific reports · 2019Article
- The subtleties of cognitive decline in multiple sclerosis: an exploratory study using hierarchichal cluster analysis of CANTAB results.BMC neurology · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
People with multiple sclerosis (MS) exhibit pronounced changes in brain structure, activity, and connectivity. While considerable work has begun to elucidate how these neural changes contribute to behavior, the heterogeneity of symptoms and diagnoses makes interpretation of findings and application to clinical practice challenging. In particular, whether MS related changes in brain activity or brain connectivity protect against or contribute to worsening motor symptoms is unclear. With the recent emergence of neuromodulatory techniques that can alter neural activity in specific brain regions, it is critical to establish whether localized brain activation patterns are contributing to (i.e. maladaptive) or protecting against (i.e. adaptive) progression of motor symptoms. In this manuscript, we consolidate recent findings regarding changes in supraspinal structure and activity in people with MS and how these changes may contribute to motor performance. Furthermore, we discuss a hypothesis suggesting that increased neural activity during movement may be either adaptive or maladaptive depending on where in the brain this increase is observed. Specifically, we outline preliminary evidence suggesting sensorimotor cortex activity in the ipsilateral cortices may be maladaptive in people with MS. We also discuss future work that could supply data to support or refute this hypothesis, thus improving our understanding of this important topic.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.