ArticleBMJ open respiratory research2017
Alcohol drinking and cigarette smoking in relation to risk of active tuberculosis: prospective cohort study.
Article in BMJ open respiratory research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 62 citations in OpenAlex.
- The short-term effect of particulate matter on tuberculosis: a time-series study in southern China.BMC infectious diseases · 2026Article
- Incidence and predictors of tuberculosis among adult diabetes mellitus patients in western Amhara comprehensive specialized hospitals, northwest Ethiopia. A multicenter retrospective follow-up study.Journal of public health research · 2026Article
- Identifying the attributes of adherence to tuberculosis treatment in Indonesia: A Delphi study.Narra J · 2025Article
- Global burden of tuberculosis attributable to diet low in whole grains from 1990 to 2021, with projection to 2045.Frontiers in nutrition · 2025Article
- Drug-Resistant Tuberculosis Hotspots in Oliver Reginald Tambo District Municipality, Eastern Cape, South Africa.Infectious disease reports · 2024Article
- Association between alcohol consumption and risk of developing tuberculosis in patients with diabetes: a nationwide retrospective cohort study.Respiratory research · 2024Article
- The effect of Mycobacterium tuberculosis treatment on thrombelastography-assessed haemostasis: a prospective cohort study.Thrombosis journal · 2024Article
- Global, regional, and national mortality of tuberculosis attributable to alcohol and tobacco from 1990 to 2019: A modelling study based on the Global Burden of Disease study 2019.Journal of global health · 2024Article
- Vulnerability of NCDs and Mediating Effect of Risk Behaviors Among Tuberculosis Patients and Their Household Contacts Compared to the General Population in the Yangon Region, Myanmar.International journal of general medicine · 2023Article
- A mixed methods study on men's and women's tuberculosis care journeys in Lusaka, Zambia-Implications for gender-tailored tuberculosis health promotion and case finding strategies.PLOS global public health · 2023Article
- Prevalence, associated factors and rifampicin resistance pattern of pulmonary tuberculosis among HIV-positive patients attending antiretroviral treatment clinic at East Gojjam Zone, Ethiopia: An institution-based cross-sectional study.Journal of clinical tuberculosis and other mycobacterial diseases · 2022Article
- Determinant factors of under-five mortality in rural Ethiopia.Annals of medicine and surgery (2012) · 2022Article
- Joint Associations of Multiple Lifestyle Factors With Risk of Active Tuberculosis in the Population: The Singapore Chinese Health Study.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2022Article
- Lifestyle changes and risk of tuberculosis in patients with type 2 diabetes mellitus: A nationwide cohort study.Frontiers in endocrinology · 2022Article
- The Effect of Diabetes and Prediabetes on Mycobacterium tuberculosis Transmission to Close Contacts.The Journal of infectious diseases · 2021Observational
- Genetic variation of ABCB1 (rs1128503, rs1045642) and CYP2E1 rs3813867 with the duration of tuberculosis therapy: a pilot study among tuberculosis patients in Indonesia.BMC research notes · 2021Article
- Factors Related to a Smoke-free Home Status: A Parental Report.Asian Pacific journal of cancer prevention : APJCP · 2021Article
- Healthful dietary patterns and risk of end-stage kidney disease: the Singapore Chinese Health Study.The American journal of clinical nutrition · 2021Article
- Patterns of tobacco and alcohol misuse among presumptive TB Patients in Myanmar: prevalence and sociodemographic associations.Nagoya journal of medical science · 2020Article
- Combined Tuberculosis and Diabetes Mellitus Screening and Assessment of Glycaemic Control among Household Contacts of Tuberculosis Patients in Yangon, Myanmar.Tropical medicine and infectious disease · 2020Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
Abstract
introductionHeavy alcohol consumption increases the risk of active tuberculosis (TB). However, the relation between lower levels of alcohol intake and TB risk remains unclear. We aimed to evaluate the association between alcohol intake and risk of active TB and assess whether the associations were modified by smoking status, which is another risk factor for active TB.
methodsThe Singapore Chinese Health Study is a prospective cohort of 63 257 adults aged 45-74 years recruited from 1993 to 1998. Information on alcohol intake and smoking history was collected at recruitment. Active TB cases were identified via linkage with National TB Notification Registry.
resultsDuring a mean follow-up of 16.8 years, 1249 incident cases of active TB were identified. Among non-smokers, compared with total abstinence, participants who had monthly to weekly intake of alcohol had reduced TB risk (HR 0.70, 95% CI 0.55 to 0.89), but this reduction in risk with low-dose drinking was not observed among current smokers (HR 0.96, 95% CI 0.77 to 1.18; p for interaction=0.02). Comparatively, drinking 2+ drinks daily was associated with increased TB risk among current smokers (HR 1.51, 95% CI 1.11 to 2.05). This increased risk was not observed among non-smokers (HR 0.93, 95% CI 0.49 to 1.77) and the interaction between alcohol intake and smoking status was of borderline significance (p for interaction=0.08). In joint effect, compared with those who neither smoked nor drank, the risk of active TB increased from 1.82 (95% CI 1.57 to 2.10) in current smokers who were non-drinkers to 3.16 (95% CI 2.35 to 4.24) in current smokers who also drank 2+ drinks daily.
conclusionWhile low intake of alcohol may protect against active TB among non-smokers, drinking 2+ drinks daily could act synergistically with smoking to increase the risk of active TB in current smokers.
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