Evidence map›Paper›PMID 29071073›Full record

ArticleBMJ open respiratory research2017

Rapid decline in lung function in healthy adults predicts incident excess urinary albumin excretion later in life.

Sapna Bhatia, Clifford Qualls, Thomas A Crowell, Alexander Arynchyn, Bharat Thyagarajan, Lewis J Smith, Ravi Kalhan, David R Jacobs, Holly Kramer, Daniel Duprez and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open respiratory research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 1 country.

Sapna BhatiaDepartment of Medicine, University of New Mexico School of Medicine, Albuquerque, New Mexico, USA.
Clifford QuallsOffice of Research, Clinical Translational Science Center,University of New Mexico, Albuquerque, New Mexico, USA.
Thomas A CrowellDepartment of Medicine, University of New Mexico School of Medicine, Albuquerque, New Mexico, USA.
Alexander ArynchynDivision of Preventive Medicine, University of Alabama at Birmingham, Birmingham, USA.
Bharat ThyagarajanDepartment of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, USA.
Lewis J SmithDepartment of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.
Ravi KalhanDepartment of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.
David R JacobsDivision of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, Minnesota, USA.
Holly KramerDepartment of Medicine, Loyola University School of Medicine, Maywood, Illinois, USA.
Daniel DuprezDepartment of Medicine, University of Minnesota, Minneapolis, USA.
Bartolome CelliBrigham and Women's Hospital, Boston, USA.
Akshay SoodDepartment of Medicine, University of New Mexico School of Medicine, Albuquerque, New Mexico, USA.
University of New Mexico · USUniversity of Minnesota · USNorthwestern University · USBrigham and Women's Hospital · USLoyola University Chicago · USUniversity of Alabama at Birmingham · US

Funding

Transitions from Impaired Respiratory Health to Lung DiseaseR01HL122477 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI RAVI KALHAN · 2014 to 2026
$17.3M
NHLBI NIH HHS R01 HL122477
6 · The paper itself

Abstract

introductionChronic lung disease, often characterised by rapid decline in lung function, is associated with vascular endothelial dysfunction (characterised by moderate to severe excess urinary albumin excretion (eUAE) but their longitudinal relationship is inadequately studied. In a bidirectional longitudinal examination of healthy adults, we analysed the following two hypotheses: (1) rapid decline (ie, highest tertile of lung function decline) predicts eUAE and (2) eUAE predicts rapid decline.

methodsWe performed a secondary data analysis from 3052 eligible participants from the Coronary Artery Risk Development in Young Adults (CARDIA) study. For analysis 1, the predictor was rapid decline in lung function between the peak value (attained at or before CARDIA visit year 10 or Y10 at a mean age of 35 years) and Y20; and the outcome was incident eUAE at Y20 and/or Y25. For analysis 2, the predictor was eUAE at Y10 and the outcome was rapid decline between Y10 and Y20.

resultsAfter adjustment for covariates in analysis 1, rapid decline in FEV

conclusionsHealthy adults with rapid decline in lung function are at risk for developing vascular endothelial dysfunction, as assessed by incident eUAE, later in life.

Indexed as

clinical epidemiology

Identifiers

PMID29071073
PMCPMC5647541
OpenAlexW2740306301

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.