ArticleJournal of virology2018
Both Sphingomyelin and Cholesterol in the Host Cell Membrane Are Essential for Rubella Virus Entry.
Article in Journal of virology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
21 citing papers in PubMed, 39 citations in OpenAlex.
- Lipidomic profiling of influenza A virus production in MDCK cells towards targeted clone selection.Scientific reports · 2026Article
- The Implication of Sphingolipids in Viral Infections.International journal of molecular sciences · 2023Review
- SiScience · 2023Article
- Article
- Rubella virus tropism and single-cell responses in human primary tissue and microglia-containing organoids.eLife · 2023Article
- Article
- Natural Ligand-Mimetic and Nonmimetic Inhibitors of the Ceramide Transport Protein CERT.International journal of molecular sciences · 2022Review
- Enhancement of Rubella Virus Infection in Immortalized Human First-Trimester Trophoblasts Under Low-Glucose Stress Conditions.Frontiers in microbiology · 2022Article
- Article
- Ceramide and Related Molecules in Viral Infections.International journal of molecular sciences · 2021Review
- Molecular and Structural Insights into the Life Cycle of Rubella Virus.Journal of virology · 2021Review
- The Epithelial-to-Mesenchymal Transition-Like Process Induced by TGF-β1 Enhances Rubella Virus Binding and Infection in A549 Cells via the Smad Pathway.Microorganisms · 2021Article
- Membrane Rafts: Portals for Viral Entry.Frontiers in microbiology · 2021Review
- The Manifold Roles of Sphingolipids in Viral Infections.Frontiers in physiology · 2021Review
- Lipidomics Issues on Human Positive ssRNA Virus Infection: An Update.Metabolites · 2020Review
- Depletion of Host and Viral Sphingomyelin Impairs Influenza Virus Infection.Frontiers in microbiology · 2020Article
- Heat Shock Protein 90 Ensures the Integrity of Rubella Virus p150 Protein and Supports Viral Replication.Journal of virology · 2019Article
- Sphingolipid biosynthesis induces a conformational change in the murine norovirus receptor and facilitates viral infection.Nature microbiology · 2018Article
- Analysis of the effect of Sphingomyelinase on rubellavirus infectivity in two cell lines.Bio-protocol · 2018Article
- Liposome Flotation Assay for Studying Interactions Between Rubella Virus Particles and Lipid Membranes.Bio-protocol · 2018Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Rubella virus (RuV) causes a systemic infection, and transplacental fetal infection causes congenital rubella syndrome. In this study, we showed that treatment of cells with sphingomyelinase inhibited RuV infection. Assays using inhibitors of serine palmitoyl transferase and ceramide transport protein demonstrated the contribution of sphingomyelin (SM) to RuV infection. Compelling evidence for direct binding of RuV to lipid membranes at neutral pH was obtained using liposome coflotation assays. The absence of either SM or cholesterol (Chol) abrogated the RuV-liposome interaction. SM and Chol (SM/Chol) were also critical for RuV binding to erythrocytes and lymphoid cells. Removal of Ca
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.