Evidence map›Paper›PMID 29070687›Full record

ArticleJournal of virology2018

Rotavirus Degrades Multiple Interferon (IFN) Type Receptors To Inhibit IFN Signaling and Protects against Mortality from Endotoxin in Suckling Mice.

Adrish Sen, Ayushi Sharma, Harry B Greenberg

Open access · bronzeAbstract read
In one paragraph

Article in Journal of virology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Analysis of intestinal epithelial cell responses tobioRxiv : the preprint server for biology · 2023
    Article
  5. Article
  6. iScience · 2023
    Review
  7. Review
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Differential Regulation of Type I and Type III Interferon Signaling.International journal of molecular sciences · 2019
    Review
  16. Article
  17. Article
  18. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Adrish SenDepartment of Microbiology and Immunology, Stanford University, Stanford, California, USA adrishs@stanford.edu hbgreen@stanford.edu.
Ayushi SharmaDepartment of Medicine, Stanford University, Stanford, California, USA.
Harry B GreenbergDepartment of Microbiology and Immunology, Stanford University, Stanford, California, USA adrishs@stanford.edu hbgreen@stanford.edu.
Stanford University · USVA Palo Alto Health Care System · US

Funding

VIRAL GASTROENTERITIS--BASIS OF PROTECTION AND VIRULENCER01AI021362 · NIAID · STANFORD UNIVERSITY · PI GREENBERG, HARRY BERNARD · 1989 to 2014
$5.4M
Regulation of Rotavirus Replication, Virulence, and Host Range Restriction by the Innate Immune SystemR01AI125249 · NIAID · PALO ALTO VETERANS INSTIT FOR RESEARCH · PI GREENBERG, HARRY BERNARD · 2017 to 2021
$2.1M
Viral Gastroenteritis: Basis of Virulence and ProtectionR56AI021362 · NIAID · PALO ALTO VETERANS INSTIT FOR RESEARCH · PI GREENBERG, HARRY BERNARD · 2015 to 2015
$506k
Regulation of Rotavirus Replication and Virulence by the Innate and Adaptive Immune SystemsR56AI125249 · NIAID · PALO ALTO VETERANS INSTIT FOR RESEARCH · PI GREENBERG, HARRY BERNARD · 2016 to 2016
$499k
Rotavirus: Studies of the Effectors and Mechanisms of Heterotypic Humoral Immunity in Human Intestinal Epithelial CellsI01BX000158 · VA · VETERANS ADMIN PALO ALTO HEALTH CARE SYS · PI GREENBERG, HARRY BERNARD · 2011 to 2022
–
BLRD VA I01 BX000158NIAID NIH HHS R01 AI021362NIAID NIH HHS R01 AI125249NIAID NIH HHS R56 AI021362NIAID NIH HHS R56 AI125249
6 · The paper itself

Abstract

STAT1 phosphorylation in response to exogenous interferon (IFN) administration can be inhibited by rotaviral replication both

Indexed as

AnimalsAnimals, SucklingCells, CulturedEndosomesEndotoxinsEpithelial CellsHEK293 CellsHT29 CellsHumansIntestinesLipopolysaccharidesLysosomesMicePhosphorylationProteolysisReceptors, InterferonEndotoxinsLipopolysaccharidesReceptors, InterferonStat1 protein, mouseSTAT1 Transcription Factorendotoxininnate immunityinterferoninterferon receptorrotavirus

Identifiers

PMID29070687
PMCPMC5730789
OpenAlexW2765983490

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.