ArticleJournal of immunology (Baltimore, Md. : 1950)2017
IL-17A-Induced PLET1 Expression Contributes to Tissue Repair and Colon Tumorigenesis.
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Article in Journal of immunology (Baltimore, Md. : 1950), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
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48citing papers in PubMed
3.7field-weighted citation impact, top 7% of its field
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Who cites it
48 citing papers in PubMed, 66 citations in OpenAlex.
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- Early Transcriptional Changes in Neutrophil-Mediated Processes Following Recanalization After Ischemic Stroke.Journal of the American Heart Association · 2026Article
- Loss of E3 ligase Ube4A Disrupts Colon Homeostasis and Accelerates Experimental Colitis via Altered Lipid Handling.bioRxiv : the preprint server for biology · 2026Article
- Sex differences in the effects of shift work-like schedules on gut microbiome and intestinal barrier in relation to stroke survival.PloS one · 2026Article
- Integrated single-cell and transcriptome sequencing data reveal the value of AOC1 in gliomas tumor microenvironment and prognosis.BMC cancer · 2025Article
- FOSL1 promotes keratinocyte migration and wound repair by modulating the IL17 signaling pathway.Scientific reports · 2025Article
- Advances of oncolytic vaccinia viruses armed with interleukin in tumor therapy.Frontiers in oncology · 2025Review
- Modulation of Plet1 expression by N-Acetylglucosamine through the IL-17 A-MAPK pathway in an imiquimod-induced psoriasis mouse model.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2024Article
- Pancreatic Epithelial IL17/IL17RA Signaling Drives B7-H4 Expression to Promote Tumorigenesis.Cancer immunology research · 2024Article
- Alveolar macrophage-expressed Plet1 is a driver of lung epithelial repair after viral pneumonia.Nature communications · 2024Article
- Immune-Mediated Inflammatory Diseases and Cancer - a dangerous liaison.Frontiers in immunology · 2024Review
- Epithelial cell invasion byVirulence · 2023Article
- The IL-17 family in diseases: from bench to bedside.Signal transduction and targeted therapy · 2023Review
- The Role of IL-17 in the Pathogenesis of Oral Squamous Cell Carcinoma.International journal of molecular sciences · 2023Review
- Article
- Cell autonomous expression of BCL6 is required to maintain lineage identity of mouse CCR6+ ILC3s.The Journal of experimental medicine · 2023Article
- Review
- SMAD4 Suppresses Colitis-associated Carcinoma Through Inhibition of CCL20/CCR6-mediated Inflammation.Gastroenterology · 2022Article
- Transcriptomic Analysis in Marine Medaka Gill Reveals That the Hypo-Osmotic Stress Could Alter the Immune Response via the IL17 Signaling Pathway.International journal of molecular sciences · 2022Article
- Colorectal Cancer in Ulcerative Colitis: Mechanisms, Surveillance and Chemoprevention.Current oncology (Toronto, Ont.) · 2022Review
Corrections and comments
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Authors and funding
19 authors at 6 institutions in 3 countries.
Jarod A ZeppDepartment of Immunology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH 44195.
Junjie ZhaoDepartment of Immunology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH 44195.
Caini LiuDepartment of Immunology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH 44195.ORCID 0000-0002-9314-7145
Katazyna BulekDepartment of Immunology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH 44195.
Ling WuDepartment of Immunology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH 44195.
Xing ChenDepartment of Immunology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH 44195.
Yujun HaoDepartment of Genetics and Genome Sciences, Case Western Reserve University School of Medicine, Cleveland, OH 44106.ORCID 0000-0002-1394-3919
Zhenghe WangDepartment of Genetics and Genome Sciences, Case Western Reserve University School of Medicine, Cleveland, OH 44106.
Xinxin WangDepartment of Microbiology and Immunology, Geisel School of Medicine, Dartmouth College, Hanover, NH 03755.
Wenjun OuyangDepartment of Immunology, Genentech, San Francisco, CA 94080.
Matthew F KaladyDepartment of Stem Cell Biology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH 44195.
Julie CarmanDiscovery Biology, Bristol Myers-Squibb, Princeton, NJ 08540.
Wen-Pin YangDiscovery Biology, Bristol Myers-Squibb, Princeton, NJ 08540.
Jun ZhuDiscovery Biology, Bristol Myers-Squibb, Princeton, NJ 08540.ORCID 0000-0002-9176-6786
Clare BlackburnMedical Research Council Centre for Regenerative Medicine, University of Edinburgh, Edinburgh EH16 4UU, United Kingdom.ORCID 0000-0002-6326-640X
Yina H HuangDepartment of Microbiology and Immunology, Geisel School of Medicine, Dartmouth College, Hanover, NH 03755.ORCID 0000-0002-0125-9351
Thomas A HamiltonDepartment of Immunology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH 44195.ORCID 0000-0002-9817-242X
Bing SuDepartment of Immunobiology and Microbiology, Shanghai Institute of Immunology, Shanghai Jiaotong University School of Medicine, Shanghai 200125, China; and lix@ccf.org bingsu@sjtu.edu.cn.ORCID 0000-0003-0871-7666
Xiaoxia LiDepartment of Immunology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH 44195; lix@ccf.org bingsu@sjtu.edu.cn.
Cleveland Clinic · USBristol-Myers Squibb (United States) · USDartmouth College · USUniversity School · USMRC Centre for Regenerative Medicine · GBShanghai Jiao Tong University · CN
Funding
TELOMERASE INACTIVATION BY RNASE L SIGNALS CELL DEATHP01CA062220 · NCI · CLEVELAND CLINIC LERNER COM-CWRU · PI LI, XIAOXIA, STARK, GEORGE ROBERT · 1994 to 2020
$35.6MVascular Cell function and AtherosclerosisP01HL029582 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI FOX, PAUL L · 1985 to 2019
$32.0MTargeting pathological hyaluronan matricesP01HL103453 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI REIZES, OFER · 2011 to 2020
$26.8MThe Cleveland Digestive Diseases Research Core Center (DDRCC)P30DK097948 · NIDDK · CASE WESTERN RESERVE UNIVERSITY · PI Theresa Torres Pizarro · 2015 to 2026
$15.6MTraining Program in Cardiovascular Biology and MedicineT32HL007843 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI THOMAS P. CAPPOLA, Sharlene M Day · 1996 to 2026
$11.0MAirway redox biochemistry as a deteriminant of asthma phenotype during adolescen*U10HL109250 · NHLBI · UNIVERSITY OF VIRGINIA · PI ERZURUM, SERPIL C., GASTON, BENJAMIN · 2011 to 2016
$4.2MImmunology Training Program-PredoctoralT32AI089474 · NIAID · CASE WESTERN RESERVE UNIVERSITY · PI COBB, BRIAN A · 2010 to 2025
$3.4MMechanisms of metabolic reprogramming by PIK3CA oncogenic mutationsR01CA196643 · NCI · CASE WESTERN RESERVE UNIVERSITY · PI Zhenghe Wang · 2016 to 2026
$3.1MMolecular and Cellular Mechanisms of IL-17 SignalingR01NS071996 · NINDS · CLEVELAND CLINIC LERNER COM-CWRU · PI LI, XIAOXIA · 2011 to 2015
$1.9MMicroenvironment Interleukin-17 and Colorectal Cancer Treatment ResistanceR01CA193359 · NCI · OHIO STATE UNIVERSITY · PI KALADY, MATTHEW FRANK · 2015 to 2019
$1.8MMolecular Medicine Training ProgramT32GM088088 · NIGMS · CLEVELAND CLINIC LERNER COM-CWRU · PI SMITH, JONATHAN D · 2011 to 2020
$1.7MHoward Hughes Medical InstituteNCI NIH HHS P01 CA062220NCI NIH HHS R01 CA193359NCI NIH HHS R01 CA196643NHLBI NIH HHS P01 HL029582NHLBI NIH HHS P01 HL103453NHLBI NIH HHS T32 HL007843NHLBI NIH HHS U10 HL109250NIAID NIH HHS T32 AI089474NIDDK NIH HHS P30 DK097948NIGMS NIH HHS T32 GM088088NINDS NIH HHS R01 NS071996
Abstract
This study identifies a novel mechanism linking IL-17A with colon tissue repair and tumor development. Abrogation of IL-17A signaling in mice attenuated tissue repair of dextran sulfate sodium (DSS)-induced damage in colon epithelium and markedly reduced tumor development in an azoxymethane/DSS model of colitis-associated cancer. A novel IL-17A target gene, PLET1 (a progenitor cell marker involved in wound healing), was highly induced in DSS-treated colon tissues and tumors in an IL-17RC-dependent manner. PLET1 expression was induced in LGR5
Indexed as
AnimalsAzoxymethaneCarcinogenesisCells, CulturedClustered Regularly Interspaced Short Palindromic RepeatsColitisColonColonic NeoplasmsDextran SulfateEpithelial CellsGene Expression Regulation, NeoplasticInterleukin-17MiceMice, Inbred C57BLMice, KnockoutPregnancy ProteinsAzoxymethaneDextran SulfateIl17rc protein, mouseInterleukin-17Plet-1 protein, mousePregnancy ProteinsReceptors, Interleukin
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.