Evidence map›Paper›PMID 29070665›Full record

ArticleNeurology2017

Blood-brain barrier leakage increases with small vessel disease in acute ischemic stroke.

Francesco Arba, Richard Leigh, Domenico Inzitari, Steven J Warach, Marie Luby, Kennedy R Lees, STIR/VISTA Imaging Collaboration

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
52citing papers in PubMed, 1 pooled it
5.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

52 citing papers in PubMed, 1 synthesis or guideline pooled it, 80 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Biomarkers of blood-brain barrier and neurovascular unit integrity in human cognitive impairment and dementia.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Review
  5. Blood-brain barrier breakdown in brain ischemia: Insights from MRI perfusion imaging.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025
    Review
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  7. Article
  8. Review
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
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  15. Article
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  18. Global changes in diffusion tensor imaging during acute ischemic stroke and post-stroke cognitive performance.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2022
    Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 3 countries.

Francesco ArbaFrom the NEUROFARBA Department (F.A., D.I.), University of Florence, Italy; National Institute of Neurological Disorders and Stroke (R.L., M.L.), NIH, Bethesda, MD; Institute of Cardiovascular and Medical Sciences (F.A.), Queen Elizabeth University Hospital, Glasgow, UK; Department of Neurology (S.J.W.), Dell Medical School, University of Texas at Austin; and Institute of Cardiovascular & Medical Sciences (K.R.L.), University of Glasgow, UK. francesco.arba@unifi.it.
Richard LeighFrom the NEUROFARBA Department (F.A., D.I.), University of Florence, Italy; National Institute of Neurological Disorders and Stroke (R.L., M.L.), NIH, Bethesda, MD; Institute of Cardiovascular and Medical Sciences (F.A.), Queen Elizabeth University Hospital, Glasgow, UK; Department of Neurology (S.J.W.), Dell Medical School, University of Texas at Austin; and Institute of Cardiovascular & Medical Sciences (K.R.L.), University of Glasgow, UK.
Domenico InzitariFrom the NEUROFARBA Department (F.A., D.I.), University of Florence, Italy; National Institute of Neurological Disorders and Stroke (R.L., M.L.), NIH, Bethesda, MD; Institute of Cardiovascular and Medical Sciences (F.A.), Queen Elizabeth University Hospital, Glasgow, UK; Department of Neurology (S.J.W.), Dell Medical School, University of Texas at Austin; and Institute of Cardiovascular & Medical Sciences (K.R.L.), University of Glasgow, UK.
Steven J WarachFrom the NEUROFARBA Department (F.A., D.I.), University of Florence, Italy; National Institute of Neurological Disorders and Stroke (R.L., M.L.), NIH, Bethesda, MD; Institute of Cardiovascular and Medical Sciences (F.A.), Queen Elizabeth University Hospital, Glasgow, UK; Department of Neurology (S.J.W.), Dell Medical School, University of Texas at Austin; and Institute of Cardiovascular & Medical Sciences (K.R.L.), University of Glasgow, UK.
Marie LubyFrom the NEUROFARBA Department (F.A., D.I.), University of Florence, Italy; National Institute of Neurological Disorders and Stroke (R.L., M.L.), NIH, Bethesda, MD; Institute of Cardiovascular and Medical Sciences (F.A.), Queen Elizabeth University Hospital, Glasgow, UK; Department of Neurology (S.J.W.), Dell Medical School, University of Texas at Austin; and Institute of Cardiovascular & Medical Sciences (K.R.L.), University of Glasgow, UK.
Kennedy R LeesFrom the NEUROFARBA Department (F.A., D.I.), University of Florence, Italy; National Institute of Neurological Disorders and Stroke (R.L., M.L.), NIH, Bethesda, MD; Institute of Cardiovascular and Medical Sciences (F.A.), Queen Elizabeth University Hospital, Glasgow, UK; Department of Neurology (S.J.W.), Dell Medical School, University of Texas at Austin; and Institute of Cardiovascular & Medical Sciences (K.R.L.), University of Glasgow, UK.
STIR/VISTA Imaging Collaboration
The University of Texas at Austin · USNational Institute of Neurological Disorders and Stroke · USQueen Elizabeth University Hospital · GBUniversity of Florence · ITUniversity of Glasgow · GB

Funding

Using MRI to Understand Disease States that Occur at the Interface of the Brain and the Cerebral CirculationZIANS003151 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI LEIGH, RICHARD · 2015 to 2023
$6.8M
6 · The paper itself

Abstract

objectiveIn patients with acute ischemic stroke, we aimed to investigate the relation between preexisting small vessel disease (SVD) and the amount of blood-brain barrier (BBB) leakage in ischemic and nonischemic area before IV thrombolysis.

methodsWe retrospectively accessed anonymous patient-level data from the Stroke Imaging Repository and the Virtual International Stroke Trials Archive resources and included patients treated with IV thrombolysis with pretreatment MRI. We rated SVD features using validated qualitative magnetic resonance (MR) scales. Leakage of BBB was assessed with postprocessing of perfusion-weighted images. We evaluated associations between SVD features (individually and summed in a global SVD score) and BBB leakage using linear regression analysis, adjusting for major clinical confounders.

resultsA total of 212 patients, mean age (±SD) 69.5 years (±16.1), 102 (48%) male, had available MR before IV thrombolysis. Evidence of BBB leakage was present in 175 (80%) and 205 (94%) patients in the ischemic and nonischemic area, respectively. Lacunar infarcts (β = 0.17,

conclusionsGlobal SVD burden is associated with increased BBB leakage in both acutely ischemic and nonischemic area. Our results support that SVD score has construct validity, and confirm a relation between SVD and BBB disruption also in patients with acute stroke.

Indexed as

AgedAged, 80 and overAnalysis of VarianceBlood-Brain BarrierBrain IschemiaCerebral Small Vessel DiseasesFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedMultivariate AnalysisStrokeTomography, X-Ray Computed

Identifiers

PMID29070665
PMCPMC5696647
OpenAlexW2765298407

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.