ReviewThe American journal of clinical nutrition2017
Emerging understanding and measurement of plasma volume expansion in pregnancy.
Review in The American journal of clinical nutrition, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers, 5 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
52 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Zinc-based therapies for prevention and treatment of vulvovaginal candidiasis: a systematic review and meta-analysis.BMC infectious diseases · 2026Pooled it
- Effect and safety of intravenous iron compared to oral iron for treatment of iron deficiency anaemia in pregnancy.The Cochrane database of systematic reviews · 2024Pooled it
- Maternal low and high hemoglobin concentrations and associations with adverse maternal and infant health outcomes: an updated global systematic review and meta-analysis.BMC pregnancy and childbirth · 2023Pooled it
- Plasma volume expansion across healthy pregnancy: a systematic review and meta-analysis of longitudinal studies.BMC pregnancy and childbirth · 2019Pooled it
- Maternal hemoglobin concentrations across pregnancy and maternal and child health: a systematic review and meta-analysis.Annals of the New York Academy of Sciences · 2019Pooled it
- Hemoglobin During Pregnancy Does Not Mediate the Relationship between Nutrition Supplements and Intrauterine Growth: A Secondary Data Analysis of Women First Preconception Nutrition Trial.The Journal of nutrition · 2025Trial
- Inadequate iron stores in early term neonates.Journal of perinatology : official journal of the California Perinatal Association · 2018Trial
- Transient high-output heart failure documented by echocardiographic cardiac index measurement in a pregnant cat.The Journal of veterinary medical science · 2026Article
- When More Is Not Better: A Balanced View of Haemoglobin Concentrations During Pregnancy.Paediatric and perinatal epidemiology · 2026Article
- Examining the Influence of Maternal and Household-Level Factors on the Global Diet Quality Score During Pregnancy in India.Maternal & child nutrition · 2026Article
- Increased Vulnerability to Dehydration Due to Heat Stress and Drought Across Reproductive States for Pastoralist Women in Northern Kenya.American journal of human biology : the official journal of the Human Biology Council · 2026Article
- Low-dose spinal anesthesia in cesarean section: a narrative review.Journal of anesthesia · 2026Review
- Eplerenone lowers maternal blood pressure in a model of leptin-induced preeclampsia, but decreases fetal growth when administered mid-, but not late-, gestation.American journal of physiology. Heart and circulatory physiology · 2026Article
- Pro-inflammatory diet in pregnancy associated with increased risk of abnormal perinatal outcomes: evidence from dietary inflammatory index in the UK biobank.Frontiers in public health · 2026Article
- Maternal anemia across pregnancy in a multi-ethnic tertiary maternity center in a Singaporean population: prevalence, risk factors, and pregnancy outcomes.Frontiers in medicine · 2026Article
- Changes in Maternal Hemoglobin Concentration and Risk of Low Birth Weight and Small-for-Gestational-Age in the United Arab Emirates: The Mutaba'ah Study.International journal of women's health · 2026Article
- Revisiting the Obesity-Anaemia Paradox: Inflammation and Iron Homeostasis in the BMI-Haemoglobin Relationship.Endocrinology, diabetes & metabolism · 2025Article
- Anaemia prevalence and risk factors among nonpregnant and pregnant women of reproductive age in Ghana: an analysis of the Ghana demographic and health survey data.Tropical medicine and health · 2025Article
- Evaluating the Chorioretinal Microcirculation in Preeclampsia with OCT-Angiography: A Narrative Literature Review.Journal of clinical medicine · 2025Review
- Associations of hemoglobin trajectories and time in target hemoglobin range with adverse pregnancy outcomes: a real-world pregnancy records-based study.Frontiers in global women's health · 2025Article
Corrections and comments
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Plasma volume expansion is an important component of a successful pregnancy. The failure of maternal plasma volume expansion has been implicated in adverse obstetric outcomes such as pre-eclampsia, fetal growth restriction, and preterm birth. Altered iron homeostasis and elevated maternal hemoglobin concentrations have also been associated with adverse pregnancy outcomes; limited data have suggested that these effects may be mediated by inadequate plasma volume expansion. In addition, it has been noted that pregnant, obese women, compared with lean subjects, have decreased plasma volume expansion along with impaired iron homeostasis and increased inflammation. Current estimates of plasma volume expansion are outdated and do not necessarily reflect contemporary obstetric populations. Moreover, the validation of clinically applicable methods of plasma volume determination as well as enhanced methodologies should be a priority. Further study is needed to characterize diminished plasma volume expansion during pregnancy and to understand the potential role of impaired iron homeostasis and inflammation in adverse obstetric outcomes, especially in obese women.
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