Evidence map›Paper›PMID 29070542›Full record

ReviewThe American journal of clinical nutrition2017

Iron homeostasis during pregnancy.

Allison L Fisher, Elizabeta Nemeth

Registry-linked trialOpen access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in The American journal of clinical nutrition, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06990373 (Establishment of Reference Intervals for Iron Test Panel for Pregnant Women at Hung Vuong Hospital), which is not on this map. Cited by 201 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
201citing papers in PubMed, 7 pooled it
12.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06990373 recruitingnot on this mapstarted 2025, after this paper: background citation

Establishment of Reference Intervals for Iron Test Panel for Pregnant Women at Hung Vuong Hospital

Typeobservational_patient_registrySponsorHung Vuong HospitalRan2025 to 2025Enrolled600ConditionsIron Deficiency (Without Anemia), Reference Values, Iron Deficiency Without Anemia
3 · Its place in the literature

Who cites it

201 citing papers in PubMed, 7 syntheses or guidelines pooled it, 380 citations in OpenAlex.

  1. Pooled it
  2. Daily oral iron supplementation during pregnancy.The Cochrane database of systematic reviews · 2024
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  19. Gestational Changes in Placental Iron Homeostasis are Associated With Ferroptosis-Associated Redox Signaling and Trophoblast Behavior.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Article
  20. Review

141 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 2 countries.

Allison L FisherMolecular, Cellular and Integrative Physiology Graduate Program and.
Elizabeta NemethCenter for Iron Disorders, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA enemeth@mednet.ucla.edu.
University of California, Los Angeles · US

Funding

Ferroportin Structure and functionR01DK107309 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI JORMAKKA, MIKA, MACKENZIE, BRYAN · 2015 to 2019
$3.0M
Training in Molecular, Cellular &Integrative PhysiologyT32GM065823 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI TIDBALL, JAMES G · 2003 to 2017
$2.1M
NIDDK NIH HHS R01 DK107309NIGMS NIH HHS T32 GM065823
6 · The paper itself

Abstract

During pregnancy, iron needs to increase substantially to support fetoplacental development and maternal adaptation to pregnancy. To meet these iron requirements, both dietary iron absorption and the mobilization of iron from stores increase, a mechanism that is in large part dependent on the iron-regulatory hormone hepcidin. In healthy human pregnancies, maternal hepcidin concentrations are suppressed in the second and third trimesters, thereby facilitating an increased supply of iron into the circulation. The mechanism of maternal hepcidin suppression in pregnancy is unknown, but hepcidin regulation by the known stimuli (i.e., iron, erythropoietic activity, and inflammation) appears to be preserved during pregnancy. Inappropriately increased maternal hepcidin during pregnancy can compromise the iron availability for placental transfer and impair the efficacy of iron supplementation. The role of fetal hepcidin in the regulation of placental iron transfer still remains to be characterized. This review summarizes the current understanding and addresses the gaps in knowledge about gestational changes in hematologic and iron variables and regulatory aspects of maternal, fetal, and placental iron homeostasis.

Indexed as

HomeostasisAnimalsDietary SupplementsFemaleFetusHepcidinsHumansIron, DietaryMaternal-Fetal ExchangeMaternal Nutritional Physiological PhenomenaModels, AnimalNutritional RequirementsPlacentaPregnancyHepcidinsIron, Dietaryanemiahepcidiniron regulationplacentapregnancy

Identifiers

PMID29070542
PMCPMC5701706
OpenAlexW2766526779

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.