ArticleAllergy & rhinology (Providence, R.I.)2017
Characterization of T-cell subpopulations in patients with chronic rhinosinusitis with nasal polyposis.
Article in Allergy & rhinology (Providence, R.I.), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 26 citations in OpenAlex.
- Pathogenic role of different phenotypes of immune cells in airway allergic diseases: a study based on Mendelian randomization.Frontiers in immunology · 2024Article
- Increased epithelial mTORC1 activity in chronic rhinosinusitis with nasal polyps.bioRxiv : the preprint server for biology · 2023Article
- Autoimmunity: A New Focus on Nasal Polyps.International journal of molecular sciences · 2023Review
- Article
- Immunological Aspects of Chronic Rhinosinusitis.Diagnostics (Basel, Switzerland) · 2022Review
- Role and Function of Regulatory T Cell in Chronic Rhinosinusitis with Nasal Polyposis.Journal of immunology research · 2022Review
- Using mass cytometry for the analysis of samples of the human airways.Frontiers in immunology · 2022Article
- Detection ofJournal of fungi (Basel, Switzerland) · 2021Article
- Investigation of the Immune Modulatory Potential of Zinc Oxide Nanoparticles in Human Lymphocytes.Nanomaterials (Basel, Switzerland) · 2021Article
- The Emerging Role of Small Extracellular Vesicles in Inflammatory Airway Diseases.Diagnostics (Basel, Switzerland) · 2021Review
- Exosomes Represent an Immune Suppressive T Cell Checkpoint in Human Chronic Inflammatory Microenvironments.Immunological investigations · 2020Article
- Influence of nasal polyp tissue on the differentiation and activation of T lymphocytes in a co-culture system.Biomedical reports · 2019Article
- Impact and Modulations of Peripheral and Edaphic B Cell Subpopulations in Chronic Rhinosinusitis With Nasal Polyposis.Clinical and experimental otorhinolaryngology · 2018Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThere is an ongoing discussion concerning the potential origins of chronic rhinosinusitis with nasal polyposis (CRSwNP).
objectiveThe aim of this study was to quantify subpopulations of T cells in peripheral blood and nasal polyps in CRSwNP to examine their influence on the etiology of this disease.
methodsTissue and blood samples were collected from 11 patients who underwent nasal sinus surgery, and these samples were analyzed by multicolor flow cytometry.
resultsThere was a significantly lower frequency of CD4+ T-helper (Th) cells and a significantly higher frequency of CD8+ T cells among lymphocytes isolated from nasal polyps compared with peripheral blood mononuclear cells (PBMC). In both T-cell subpopulations, a shift mainly from naive T cells among peripheral blood lymphocytes toward an effector memory and terminally differentiated subtype predominance in nasal polyps was observed. Among CD4+ T cells, the frequencies of cluster of differentiation (CD) 45RA- Forkhead-Box-Protein P3high (FoxP3high) cytotoxic T-lymphocyte-associated Protein 4high (CTLA-4high) activated regulatory T (Treg) cells, and CD45RA- Forkhead-Box-Protein P3low (FoxP3low) memory T cells were significantly increased in nasal polyps compared with PBMC.
conclusionIn this study, we presented a detailed characterization of CD4+ and CD8+ T-cell subpopulations in patients with CRSwNP. CD8+ T cells were more prominent in nasal polyps than in CD4+ T cells. Both nasal CD8+ T cells and CD4+ T cells predominantly had an effector memory phenotype. Among CD4+ T cells, activated Treg cells were increased in nasal polyps compared with PBMC. The data point toward a local regulation of T-cell composition within the microenvironment of nasal polyps, which might be further exploited in the future to develop novel immunotherapeutic strategies.
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Registered trials
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