ArticleMicrobiome2017
Microbial biodiversity assessment of the European Space Agency's ExoMars 2016 mission.
Article in Microbiome, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Microbiome in a ground-based analog cabin of China Space Station during a 50-day human occupation.ISME communications · 2024Article
- Development of Martian saline seep models and their implications for planetary protection.Biofilm · 2023Article
- Bacterial and fungal bioburden reduction on material surfaces using various sterilization techniques suitable for spacecraft decontamination.Frontiers in microbiology · 2023Article
- Whole genome sequencing of cyanobacteriumiScience · 2022Article
- Riboflavin- and chlorophyllin-based antimicrobial photoinactivation ofFrontiers in cellular and infection microbiology · 2022Article
- Assembly of Bacterial Genome Sequences from Metagenomes of Spacecraft Assembly Cleanrooms.Microbiology resource announcements · 2021Article
- Antimicrobial Photoinactivation Approach Based on Natural Agents for Control of Bacteria Biofilms in Spacecraft.International journal of molecular sciences · 2020Review
- Prokaryotic and Fungal Characterization of the Facilities Used to Assemble, Test, and Launch the OSIRIS-REx Spacecraft.Frontiers in microbiology · 2020Article
- Microbial Monitoring in the EDEN ISS Greenhouse, a Mobile Test Facility in Antarctica.Frontiers in microbiology · 2020Article
- Microbiomes of China's Space Station During Assembly, Integration, and Test Operations.Microbial ecology · 2019Article
- Microbial activity in Martian analog soils after ionizing radiation: implications for the preservation of subsurface life on Mars.AIMS microbiology · 2018Article
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe ExoMars 2016 mission, consisting of the Trace Gas Orbiter and the Schiaparelli lander, was launched on March 14 2016 from Baikonur, Kazakhstan and reached its destination in October 2016. The Schiaparelli lander was subject to strict requirements for microbial cleanliness according to the obligatory planetary protection policy. To reach the required cleanliness, the ExoMars 2016 flight hardware was assembled in a newly built, biocontrolled cleanroom complex at Thales Alenia Space in Turin, Italy. In this study, we performed microbiological surveys of the cleanroom facilities and the spacecraft hardware before and during the assembly, integration and testing (AIT) activities.
methodsBesides the European Space Agency (ESA) standard bioburden assay, that served as a proxy for the microbiological contamination in general, we performed various alternative cultivation assays and utilised molecular techniques, including quantitative PCR and next generation sequencing, to assess the absolute and relative abundance and broadest diversity of microorganisms and their signatures in the cleanroom and on the spacecraft hardware.
resultsOur results show that the bioburden, detected microbial contamination and microbial diversity decreased continuously after the cleanroom was decontaminated with more effective cleaning agents and during the ongoing AIT. The studied cleanrooms and change room were occupied by very distinct microbial communities: Overall, the change room harboured a higher number and diversity of microorganisms, including Propionibacterium, which was found to be significantly increased in the change room. In particular, the so called alternative cultivation assays proved important in detecting a broader cultivable diversity than covered by the standard bioburden assay and thus completed the picture on the cleanroom microbiota.
conclusionDuring the whole project, the bioburden stayed at acceptable level and did not raise any concern for the ExoMars 2016 mission. The cleanroom complex at Thales Alenia Space in Turin is an excellent example of how efficient microbiological control is performed.
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