ArticleBMC anesthesiology2017
The obesity conundrum in sepsis.
Article in BMC anesthesiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
37 citing papers in PubMed, 55 citations in OpenAlex.
- Body mass index and risk of dying from a bloodstream infection: A Mendelian randomization study.PLoS medicine · 2020Trial
- Deep learning-derived abdominal adiposity phenotypes and 28-day mortality in sepsis.International journal of obesity (2005) · 2026Article
- Do Obesity Classifications Create the Obesity Paradox? A Scoping Review of Obesity Definitions Applied in Sepsis Research.Clinical obesity · 2026Article
- WEIGHT LOSS-INDUCED ADIPOSE MACROPHAGE MEMORY CORRESPONDS WITH LOWER ADIPOSE BACTERIAL BURDEN IN MURINE SYSTEMIC STAPHYLOCOCCUS AUREUS INFECTION.Shock (Augusta, Ga.) · 2025Article
- The nonlinear correlation of neutrophil-lymphocyte ratio on 1-year mortality risk in patients with severe acute heart failure.BMC cardiovascular disorders · 2025Article
- Factors influencing sepsis associated thrombocytopenia (SAT): A multicenter retrospective cohort study.PloS one · 2025Observational
- Sepsis-induced changes in pyruvate metabolism: insights and potential therapeutic approaches.EMBO molecular medicine · 2024Review
- A new frontier for fat: dietary palmitic acid induces innate immune memory.Immunometabolism (Cobham, Surrey) · 2023Review
- Association between obesity and 1-year mortality in septic patients: a retrospective cohort study.BMJ open · 2023Article
- Effect of Fluid Resuscitation Strategies for Obese Patients with Sepsis and Septic Shock: A Systematic Review.Intensive care research · 2023Review
- Article
- The associations between body composition and vital capacity index of medical students in Shenyang of China: a cross-sectional survey.BMC pulmonary medicine · 2022Article
- Spinal level and cord involvement in the prediction of sepsis development after vertebral fracture repair for traumatic spinal injury.Journal of neurosurgery. Spine · 2022Article
- Underweight but not overweight is associated with excess mortality in septic ICU patients.Wiener klinische Wochenschrift · 2022Article
- The effect of body mass index on the development of acute kidney injury and mortality in intensive care unit: is obesity paradox valid?Renal failure · 2021Article
- Divergent Sepsis Pathophysiology in Older Adults.Antioxidants & redox signaling · 2021Review
- Pulmonary infection induces persistent, pathogen-specific lipidomic changes influencing trained immunity.iScience · 2021Article
- Impact of Body Mass Index on the Survival of Patients with Sepsis with Different Modified NUTRIC Scores.Nutrients · 2021Article
- Neutropenic enterocolitis-induced sepsis and disseminated intravascular coagulation after chemotherapy: a case report.BMC women's health · 2021Article
- The swedish covid-19 intensive care cohort: Risk factors of ICU admission and ICU mortality.Acta anaesthesiologica Scandinavica · 2021Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
While the long-term negative effects of obesity on health is a well-studied phenomenon, its effects on acute illnesses seem to be the contrary. Several studies have indicated the possibility of an 'obesity paradox' in sepsis - where overweight and obese patients have better outcomes than normal weight patients. These meta-analyses including large numbers of patients across different countries raised an interesting but debatable topic. Results from meta-analyses of observational studies should be interpreted with caution, and a prove of association not be mistaken as prove of causality. Limitations common to such studies include inadequate adjustment for confounding and selection bias. More rigorous investigations to clarify any causal relationship between obesity and mortality in sepsis are needed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.