ArticleBMC gastroenterology2017
Longitudinal study of gastroesophageal reflux and erosive tooth wear.
Article in BMC gastroenterology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02087345 (Gastro-oesophageal Reflux in Oligosymptomatic Patients With Dental Erosion), which is not on this map. Cited by 12 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Gastro-oesophageal Reflux in Oligosymptomatic Patients With Dental Erosion: a Longitudinal Study With pH-impedance Monitoring
Who cites it
12 citing papers in PubMed, 2 syntheses or guidelines pooled it, 25 citations in OpenAlex.
- Relationship Between Laryngopharyngeal Reflux, Gastroesophageal Reflux Disease, and Dental Erosion in Adult Populations: A Systematic Review.Digestive diseases and sciences · 2025Pooled it
- Laryngopharyngeal reflux, gastroesophageal reflux and dental disorders: A systematic review.PloS one · 2020Pooled it
- In vitro study on the neutralization potential of particulate hydroxyapatite in erosive acids.BDJ open · 2026Article
- Evidence-based recommendations for diagnosing and managing dentine hypersensitivity in clinical practice: insights from the Middle East and Africa.Frontiers in oral health · 2025Review
- Prevalence and Risk of Dental Erosion in Patients with Gastroesophageal Reflux Disease: A Meta-Analysis.Dentistry journal · 2022Article
- Relationship between erosive tooth wear and possible etiological factors among dental students.Clinical oral investigations · 2022Article
- Analysis of laboratory adhesion studies in eroded enamel and dentin: a scoping review.Biomaterial investigations in dentistry · 2021Article
- Effect of Duodenogastric Reflux on Dental Enamel.Oral health & preventive dentistry · 2020Article
- Clinical Quantitative Evaluation of Tooth Wear: A 4-year Longitudinal Study.Oral health & preventive dentistry · 2020Article
- Obesity and tooth wear among American adults: the role of sugar-sweetened acidic drinks.Clinical oral investigations · 2020Article
- Factors associated with dental erosions in gastroesophageal reflux disease: a cross-sectional study in patients with heartburn.Medicine and pharmacy reports · 2020Article
- Gastro-oesophageal reflux - an important causative factor of severe tooth wear in Prader-Willi syndrome?Orphanet journal of rare diseases · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundApproximately 60% of patients presenting to dentists with erosive tooth wear have significant gastroesophageal reflux (GERD), despite minor reflux symptoms. No longitudinal studies of reflux-associated erosive tooth wear and of reflux characteristics have been reported to date. The aim of this study was to characterize the longitudinal course of GERD and of associated erosive tooth wear, as well as factors predictive of its progression, in a large group of patients.
methodsSeventy-two patients presenting to dentists with clinically significant erosive tooth wear and increased esophageal acid exposure by 24-h multichannel intraluminal pH-impedance measurement (MII-pH) were re-assessed clinically and by MII-pH after 1 year treatment with esomeprazole 20 mg twice-daily. Predictive factors for erosive tooth wear were assessed by logistic regression.
resultsAt follow-up, no further progression in erosive tooth wear was observed in 53 (74%) of patients. The percentage of time with a pH < 4, the number of acid reflux episodes and the percentage of proximal esophageal reflux off-PPI did not change significantly after one year, but the number of weakly acidic reflux episodes decreased significantly in the large subgroup without progression. None of the baseline demographic, clinical, endoscopic or esophageal acid exposure characteristics were significantly associated with progression of erosive tooth wear at follow-up.
conclusionsIn this longitudinal study in patients with erosive tooth wear and oligosymptomatic GERD receiving esomeprazole for one year, erosive tooth wear did not progress further in the majority of patients. Background acidic esophageal reflux exposure appeared stable over time, whereas weakly acidic exposure decreased significantly in patients without erosion progression. MII-pH measurements on-PPI and with healthy controls will be useful in the further elucidation of the causal role of reflux in erosive tooth wear.
trial registrationClinicalTrials.gov , retrospectively registered: NCT02087345 .
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.