Evidence map›Paper›PMID 29069944›Full record

ReviewDrug delivery2017

Photosensitive drugs: a review on their photoprotection by liposomes and cyclodextrins.

Giuseppina Ioele, Michele De Luca, Antonio Garofalo, Gaetano Ragno

Abstract readReview
In one paragraph

Review in Drug delivery, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed.

  1. Article
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  5. Review
  6. Cyclodextrins and Their Derivatives as Drug Stability Modifiers.Pharmaceuticals (Basel, Switzerland) · 2023
    Review
  7. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Giuseppina Ioelea Department of Pharmacy and Health and Nutrition Sciences , University of Calabria , Rende (CS) , Italy.
Michele De Lucaa Department of Pharmacy and Health and Nutrition Sciences , University of Calabria , Rende (CS) , Italy.
Antonio Garofaloa Department of Pharmacy and Health and Nutrition Sciences , University of Calabria , Rende (CS) , Italy.
Gaetano Ragnoa Department of Pharmacy and Health and Nutrition Sciences , University of Calabria , Rende (CS) , Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nowadays, an exciting challenge in the drug chemistry and technology research is represented by the development of methods aimed to protect molecular integrity and therapeutic activity of drugs from effects of light. The photostability characterization is ruled by ICH (The International Council for Harmonization of Technical Requirements for Pharmaceuticals for Human Use), which releases details throughout basic protocols of stability tests to be performed on new medicinal products for human use. The definition of suitable photoprotective systems is fundamental for pharmaceutical manufacturing and for human healthy as well, since light exposure may affect either drugs or drug formulations giving rise even to allergenic or mutagenic by-products. Here, we summarize and discuss the recent studies on the formulation of photosensitive drugs into supramolecular systems, capable of entrapping the molecules in a hollow of their structure by weak noncovalent interactions and protecting them from light. The best known supramolecular matrices belong to the 'auto-assembled' structures, of which liposomes are the most representative, and the 'host-guest' systems, of which cyclodextrins represent the most common 'host' counterpart. A relevant number of papers concerning the use of both liposomes and cyclodextrins as photoprotection systems for drugs has been published over the last 20 years, demonstrating that this topic captures interest in an increasing number of researchers.

Indexed as

Chemistry, PharmaceuticalCyclodextrinsDrug StabilityHumansLiposomesPhotosensitizing AgentsProtective AgentsCyclodextrinsLiposomesPhotosensitizing AgentsProtective AgentsPhotolabile drugsphotoprotectionphototoxicitystability testssupramolecular matrices

Identifiers

PMID29069944
PMCPMC8812581

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.