ArticleOncotarget2017
The recurrence risk of neural tube defects (NTDs) in a population with high prevalence of NTDs in northern China.
Article in Oncotarget, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed, 2 syntheses or guidelines pooled it, 24 citations in OpenAlex.
- Prevalence of neural tube defects and their associated factors in Sub-Saharan Africa: a systematic review.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2025Pooled it
- Magnitude and determinants of neural tube defect in Africa: a systematic review and meta-analysis.BMC pregnancy and childbirth · 2021Pooled it
- Risk factors for neural tube defects in the war and siege-affected tigray regional state of ethiopia: a case-control study.BMC pregnancy and childbirth · 2025Article
- Neural tube defects in a war-torn Tigray regional state of Ethiopia: a retrospective study of 54,626 deliveries.BMC pregnancy and childbirth · 2025Article
- Study on the relationship between genetic polymorphism of reductive folic acid carrier and the risk of neural tube defects.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2023Article
- Neural tube defects: a review of global prevalence, causes, and primary prevention.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2023Review
- Periconceptional folic acid and risk for neural tube defects among higher risk pregnancies.Birth defects research · 2019Article
- Advanced glycation end products induce neural tube defects through elevating oxidative stress in mice.Neural regeneration research · 2018Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundAlthough a number of studies have reported the recurrence risk of NTDs in developed countries, there is little data on the rate of recurrence of NTDs in northern China, a region of high prevalence of NTDs.
methodsBased on the population-based birth defects surveillance system of five counties, we identified women who had an NTD affected pregnancy from 2004-2015 and a retrospective survey was conducted. The rate of recurrence of NTDs was calculated by the number of recurrent NTDs divided by the first NTDs. Maternal age, body mass index (BMI), gestational weeks, education, and occupation were collected. Information on folic acid (FA) supplements, time and dosage were also recorded.
resultsAmong 851 women who had a previous NTD-affected pregnancy, there were 578 subsequent pregnancies, with 10 recurrent NTDs, a 1.7% recurrence rate. The recurrence rate was 1.5% and 2.6% for those taking FA supplements and without FA supplementation respectively. Women with recurrent NTDs had higher BMI before pregnancy compared to those who had a second pregnancy without NTDs. Among the recurrent NTDs, the majority were spina bifida.
conclusionsThe recurrence rate of NTDs was approximately five times higher than the overall prevalence in the same region of northern China. Risk of recurrence appeared lower among women who took FA supplements. These findings are consistent with the reduction in NTD frequency in the population since introduction of the nationwide FA supplement program. Data on recurrence rates in northern China will inform power calculations for future intervention studies.
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